Further nonlinearities in neurovascular coupling in rodent barrel cortex
Further nonlinearities in neurovascular coupling in rodent barrel cortex
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DOI：
10.1016/j.neuroimage.2004.08.040
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发表时间：
2005-01-15
期刊：
影响因子：
5.7
通讯作者：
Mayhew, J
中科院分区：
文献类型：
--
作者：
Hewson-Stoate, N;Jones, M;Mayhew, J
准确解释无创功能性脑成像技术（如血氧水平依赖（BOLD） fMRI）的必要前提是彻底理解神经活动和血流动力学反应之间的耦合关系。本研究以大鼠桶状皮层为模型研究了这种关系。通过对多层流场电位应用电流源密度（CSD）分析来测量神经输入，以消除单电极记录中固有信号来源的模糊性。用激光多普勒血流仪记录脑血流的变化。通过改变电须垫刺激的强度和频率，神经和脑血流反应的幅度在很大范围内被调节。与先前的研究结果一致[Devor， A.等，2003]。神经学报39,353-359；Sheth， S.A等人，2004。神经元42,347-355]幂律函数很好地描述了神经和血流动力学之间的关系。尽管整个数据集的耦合活动是非线性的，但这种关系可以很好地近似为中范围刺激的线性函数。改变1.2 mA的刺激频率会改变沿线性区域的神经活动和相应的血流动力学反应，这与最近关于非线性关系的报道相一致[Devor， a .等，2003]。神经学报39,353-359；琼斯，M.等人，2004。神经影像22,956-965；Sheth, s.a. . .Et al., 2004。神经元42,347-355]与先前的研究发现，当改变刺激频率时，线性耦合关系[Martindale， J., et, 2003]。j . Cereb。中华血液学杂志23,546-555；杨建平等，1999。中国生物医学工程学报（英文版）；Sheth， S.等人，2003。神经影像19,884-894]。在影像学研究中使用线性范围内的刺激可以简化对结果的解释。(C) 2004爱思唯尔公司版权所有。
An essential prerequisite for the accurate interpretation of noninvasive functional brain imaging techniques, such as blood oxygen level dependent (BOLD) fMRI, is a thorough understanding of the coupling relationship between neural activity and the haemodynamic response. The current study investigates this relationship using rat barrel cortex as a model. Neural input was measured by applying current source density (CSD) analysis to multi-laminar field potentials to remove ambiguities regarding the origin of the signal inherent in single electrode recordings. Changes in cerebral blood flow (CBF) were recorded with a laser Doppler flowmetry probe. The magnitude of neural and CBF responses were modulated over a large range by altering both the intensity and frequency of electrical whisker pad stimulation. Consistent with previous findings [Devor, A., et al., 2003. Neuron 39, 353-359; Sheth, S.A., et al., 2004. Neuron 42, 347-355] a power law function well described the relationship between neuraly and haemodynamics. Despite the nonlinearity of the coupling activity over the whole data set, the relationship was very well approximated by a linear function over mid-range stimuli. Altering the frequency of stimulation at 1.2 mA shifted the neural activity and corresponding haemodynamic response along this linear region, reconciling recent reports of a nonlinear relationship [Devor, A., et al., 2003. Neuron 39, 353-359; Jones, M., et al., 2004. NeuroImage 22, 956-965; Sheth, S.A.. et al., 2004. Neuron 42, 347-355] with previous work that found a linear coupling relationship when altering stimulation frequency [Martindale, J., et al., 2003. J. Cereb. Blood Flow Metab. 23, 546-555; Ngai, A.C., et al., 1999. Brain Res. 837, 221-228; Sheth, S., et al., 2003. NeuroImage 19, 884-894]. Using stimuli within this linear range in imaging studies would simplify the interpretation of findings. (C) 2004 Elsevier Inc. All rights reserved.