2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, enhances the adhesion of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes
2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, enhances the adhesion of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes
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DOI：
10.1016/j.febslet.2005.10.030
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发表时间：
2005-11-21
期刊：
影响因子：
3.5
通讯作者：
Sugiura, T
中科院分区：
文献类型：
--
作者：
Gokoh, M;Kishimoto, S;Sugiura, T
2-花生四烯酰甘油 (2-AG) 是一种内源性大麻素受体（CB1 和 CB2）配体，可增强分化为巨噬细胞样细胞的 HL-60 细胞对纤连蛋白和血管细胞粘附分子-1 的粘附。 CB2 受体、Gi/Go、细胞内游离 Ca2+ 和磷脂酰肌醇 3-激酶被证明参与 2-AG 诱导的细胞粘附增强。 2-AG还增强人单核细胞白血病U937细胞与外周血单核细胞的粘附。这些结果强烈表明，2-AG 通过诱导多种类型炎症细胞和免疫活性细胞中细胞外基质蛋白和粘附分子的牢固粘附，在炎症反应和免疫反应中发挥重要作用。 (c) 2005 年欧洲生化学会联合会。由 Elsevier B.V. 出版。保留所有权利。
2-Arachidonoylglycerol (2-AG), an endogenous cannabionoid receptor (CB1 and CB2) ligand, enhanced the adhesion of HL-60 cells differentiated into macrophage-like cells to fibronectin and the vascular cell adhesion molecule-1. The CB2 receptor, Gi/Go, intracellular free Ca2+ and phosphatidylinositol 3-kinase were shown to be involved in 2-AG-induced augmented cell adhesion. 2-AG also enhanced the adhesion of human monocytic leukemia U937 cells and peripheral blood monocytes. These results strongly suggest that 2-AG plays some essential role in inflammatory reactions and immune responses by inducing robust adhesion to extracellular matrix proteins and adhesion molecules in several types of inflammatory cells and immune-competent cells. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.