Can preoperative CEA and CA19-9 serum concentrations suggest metastatic disease in colorectal cancer patients?
Can preoperative CEA and CA19-9 serum concentrations suggest metastatic disease in colorectal cancer patients?
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DOI：
10.1967/s002449910505
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发表时间：
2017-01-01
影响因子：
1.5
通讯作者：
Krivokapic, Zoran
中科院分区：
文献类型：
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作者：
Lalosevic, Milica Stojkovic;Stankovic, Sanja;Krivokapic, Zoran
目的：探讨术前血清癌胚抗原（CEA）和糖链癌抗原（CA 19 -9）水平对结直肠癌（CRC）伴肝转移和淋巴结转移的诊断价值。受试者和方法：2014年5月至2015年3月期间，共有300例组织学诊断为CRC的患者纳入本研究。从患者的病历中前瞻性地获得数据：病史、人口统计学、肿瘤位置、分化（等级）、肿瘤深度（T）、淋巴结转移（N）、远处转移（M）、淋巴结转移、静脉和神经周围浸润以及疾病分期。肿瘤标志物测定采用电化学发光法，参考值CEA为5 ng/ml，Ca 19 -9为37 u/ml。结果：不同临床分期的大肠癌患者血清CEA、CA 19 -9水平差异有统计学意义（P
OBJECTIVE:This study was designed to investigate the efficiency of preoperative serum carcinoembryonic antigen (CEA) and carbohydrate cancer antigen (CA19-9) levels for diagnosing synchronous liver metastases and lymph node in colorectal carcinoma (CRC) patients. SUBJECTS AND METHODS:A total of 300 patients with histologically diagnosed CRC were included in this study between May 2014 and March 2015. The data were obtained prospectively from patient's medical records: medical history, demographics, tumor location, differentiation (grade), depth of the tumor (T), lymph node metastases (N), distant metastases (M), lymphatics, venous and perineural invasion, and disease stage. Tumor markers were measured with an electrochemiluminescent assay and the reference value was 5ng/ml for CEA and for Ca19-9, 37u/ml. RESULTS:There was A high statistically significant difference in the levels of serum CEA and CA19-9 between different disease stages of CRC (P