Investigation of changes in body composition, metabolic profile and skeletal muscle functional capacity in ischemic stroke patients: the rationale and design of the Body Size in Stroke Study (BoSSS).
Investigation of changes in body composition, metabolic profile and skeletal muscle functional capacity in ischemic stroke patients: the rationale and design of the Body Size in Stroke Study (BoSSS).
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DOI：
10.1007/s13539-013-0103-0
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发表时间：
2013-09
影响因子：
8.9
通讯作者：
Doehner, Wolfram
中科院分区：
文献类型：
--
作者：
Knops, Michael;Werner, Claudia G.;Scherbakov, Nadja;Fiebach, Jochen;Dreier, Jens P.;Meisel, Andreas;Heuschmann, Peter U.;Jungehuelsing, Gerd J.;von Haehling, Stephan;Dirnagl, Ulrich;Anker, Stefan D.;Doehner, Wolfram
关键词：
中风的患病率正在稳步上升。卒中常可观察到肌肉组织萎缩和功能改变，但目前尚未对此进行详细研究。关于如何针对中风患者的肌肉萎缩，缺乏数据支持指南建议。我们假设卒中患者的病理生理代谢特征以及肌肉功能和结构损伤正在发展，这与卒中的严重程度和卒中后的预后有关。卒中中的身体大小研究(BOSS)是一项前瞻性的纵向观察研究，旨在探索中风患者代谢特征、身体组织浪费与骨骼肌组织特定代谢和功能变化之间的关系。连续的急性卒中患者(n = 150)将因大脑中动脉区域的腔隙或区域性缺血性梗塞而入选。患者将在12个月和24个月后每年进行一次研究。作为对比，年龄相近的健康对照组和慢性心力衰竭患者将作为对照组。主要目的是研究中风患者身体成分的变化。其次，这项研究将重点关注脂肪组织和骨骼肌对胰岛素敏感性的变化。此外，血管内皮功能和外周血流量的测量将为中风患者的血管调节提供洞察力。这项研究将是对急性缺血性中风患者肌肉组织代谢和功能变化的最大规模的观察性研究。这些新的数据将增加我们对中风疾病中病理生理组织浪费的理解，并有助于开发新的治疗策略。
Stroke is steadily increasing in prevalence. Muscle tissue wasting and functional changes are frequently observed in stroke, but this has not been studied in detail yet. There is a lack of data to support guideline recommendations on how to target muscle wasting in stroke patients. We hypothesise that pathophysiological metabolic profiles and muscle functional and structural impairment are developing in stroke patients, which are associated with stroke severity and outcome after stroke. The Body Size in Stroke Study (BoSSS) is a prospective, longitudinal observation study that will explore associations between the metabolic profile, body tissue wasting and particular metabolic and functional changes in skeletal muscle tissue in stroke patients. Consecutive patients with acute stroke (n = 150) will be enrolled due to lacunar or territorial ischemic infarct in the area of the middle cerebral artery. Patients will be studied at annual intervals after 12 and 24 months. For comparison, healthy controls of similar age and patients with chronic heart failure will be used as control groups. The main objective is to study changes in body composition in stroke patients. Secondary, the study will focus on changes in insulin sensitivity of adipose tissue and skeletal muscle. Furthermore, measurements of endothelial function and peripheral blood flow will provide insight in the vascular regulation in stroke patients. This study will be the largest observational study providing insights into the metabolic and functional changes of muscle tissue in patients with acute ischemic stroke. The new data will increase our understanding of the pathophysiologic tissue wasting in stroke disease and help to develop new therapeutic strategies.
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DOI：
10.1682/jrrd.2007.02.0040
发表时间：
2008-01-01
影响因子：
--
作者：
Hafer-Macko, Charlene E.;Ryan, Alice S.;Macko, Richard F.
通讯作者：
Macko, Richard F.
影响因子：
8.3
作者：
Hafer-Macko, CE;Yu, SZ;Macko, RF
通讯作者：
Macko, RF
影响因子：
168.9
作者：
Barber, PA;Demchuk, AM;Buchan, AM
通讯作者：
Buchan, AM
影响因子：
8.3
作者：
FASSBENDER, K;SCHMIDT, R;HENNERICI, M
通讯作者：
HENNERICI, M
影响因子：
8.3
作者：
Boschmann, M;Engeli, S;Jordan, J
通讯作者：
Jordan, J