Pneumococcal pneumonia and influenza: A deadly combination
Pneumococcal pneumonia and influenza: A deadly combination
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DOI：
10.1016/j.vaccine.2009.06.007
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发表时间：
2009-08-21
期刊：
影响因子：
5.5
通讯作者：
Madhi, Shabir A.
中科院分区：
文献类型：
--
作者：
Klugman, Keith P.;Chien, Yu-Wen;Madhi, Shabir A.
肺炎球菌合并感染导致的显著发病率与病毒性呼吸道感染有关。肺炎是全世界儿童死亡的主要原因。美国儿童临床肺炎的发病率在引入七价肺炎球菌结合疫苗（PCV）后下降了39%。PCV还减少了儿童流感相关的住院治疗。与1918年流感大流行相关的大多数死亡率可归因于细菌感染，特别是肺炎球菌。儿童接种PCV疫苗和成人接种肺炎球菌多糖疫苗应被视为大流行性流感防备的必要条件。(C)2009爱思唯尔有限公司保留所有权利。
Significant morbidity due to pneumococcal co-infection is associated with viral respiratory infections. Pneumonia is the leading cause of death in children worldwide. The incidence of clinical pneumonia among children in the United States decreased 39% following the introduction of a seven-valent pneumococcal conjugate vaccine (PCV). PCVs have also reduced hospitalisations associated with influenza in children. The majority of the mortality associated with the influenza pandemic of 1918 was attributable to bacterial infections, especially the pneumococcus. Vaccination with PCV for children and pneumococcal polysaccharide vaccine for adults should be considered essential to pandemic influenza preparedness. (C) 2009 Elsevier Ltd. All rights reserved.