Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study
Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study
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DOI：
10.1007/s10654-020-00614-7
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发表时间：
2020-02-25
影响因子：
13.6
通讯作者：
Scherjon, Sicco A.
中科院分区：
文献类型：
--
作者：
Warmink-Perdijk, Willemijn D. B.;Peters, Lilian L.;Scherjon, Sicco A.
流行病学研究表明，孕前、产前、出生和生命早期因素与终身健康之间有着密切的关系。生命线NEXT是一个出生队列，旨在研究四代设计中内在和外在决定因素对健康和疾病的影响。它被嵌入到生命线队列研究中，这是一项前瞻性的三代人群队列研究，记录了生活在荷兰北方的167，729人的健康和健康相关方面。在生命线下一个，我们的目标是包括1500怀孕的生命线参与者，并集中跟踪他们，他们的伴侣和他们的孩子，直到出生后至少1年。随后将按照生命线程序对身体和心理健康进行长期随访。在生命线NEXT研究期间，将在10个时间点从母亲和儿童中收集生物材料，包括母亲和新生儿（脐带）血、胎盘组织、粪便、母乳、鼻拭子和尿液。我们还将通过14个不同时间点的问卷调查收集有关医疗、社会、生活方式和环境因素的数据，并通过联网设备收集连续数据。在怀孕期间和之后从母亲和孩子广泛收集不同的（生物）材料将提供将环境因素（包括母亲和新生儿微生物组组成）与（表观）遗传学、健康和发育结果相关联的手段。在生命线内嵌套的研究使我们能够包括前概念的跨代数据，并可用于确定队列中的其他大家庭。
Epidemiological research has shown there to be a strong relationship between preconceptional, prenatal, birth and early-life factors and lifelong health. The Lifelines NEXT is a birth cohort designed to study the effects of intrinsic and extrinsic determinants on health and disease in a four-generation design. It is embedded within the Lifelines cohort study, a prospective three-generation population-based cohort study recording the health and health-related aspects of 167,729 individuals living in Northern Netherlands. In Lifelines NEXT we aim to include 1500 pregnant Lifelines participants and intensively follow them, their partners and their children until at least 1 year after birth. Longer-term follow-up of physical and psychological health will then be embedded following Lifelines procedures. During the Lifelines NEXT study period biomaterials-including maternal and neonatal (cord) blood, placental tissue, feces, breast milk, nasal swabs and urine-will be collected from the mother and child at 10 time points. We will also collect data on medical, social, lifestyle and environmental factors via questionnaires at 14 different time points and continuous data via connected devices. The extensive collection of different (bio)materials from mother and child during pregnancy and afterwards will provide the means to relate environmental factors including maternal and neonatal microbiome composition) to (epi)genetics, health and developmental outcomes. The nesting of the study within Lifelines enables us to include preconceptional transgenerational data and can be used to identify other extended families within the cohort.