Prognostic factors associated with COVID-19 related severity in sickle cell disease.
Prognostic factors associated with COVID-19 related severity in sickle cell disease.
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DOI：
10.1016/j.bcmd.2021.102627
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Shi PA
中科院分区：
文献类型：
--
作者：
Yurtsever N;Nandi V;Ziemba Y;Shi PA
认为镰状细胞病(SCD)是新冠肺炎严重程度的危险因素，以及在SCD中增加新冠肺炎严重程度的风险的变量存在均衡。鉴于我们的卫生系统有大量SCD患者，我们分析了自己在这方面的经验。回顾分析2020年3月1日至12月31日通过诺斯韦尔卫生系统确诊的新冠肺炎确诊的SCD患者的临床病程及其住院和ICU相关因素。在1,098例SCD患者中，3.3%的患者被诊断为新冠肺炎。总的住院率、ICU住院率、队列死亡率和住院死亡率分别为80%、19%、2.5%和3.1%。多变量分析显示，入院Hb每增加1 g/dL，住院风险降低60%。作为一名卫生保健工作者，ICU入院风险增加了84%；入院未成熟粒细胞计数每增加1000个/uL，入院风险增加45%；使用羟基尿素后，入院风险降低17%。与普通人群相比，SCD患者高住院率与新冠肺炎感染严重程度的恶化是一致的。患者应该服用羟基脲，以提高他们的Hb，或许还可以降低他们的中性粒细胞计数。患有SCD的医护人员可能需要采取特别的安全措施。
Equipoise exists regarding sickle cell disease (SCD) as a risk factor for COVID-19 disease severity and variables that increase risk of COVID-19 severity in SCD. Given our health system's large SCD patient catchment, we analyzed our own experience in this regard. Retrospective analysis of the clinical course and factors associated with need for hospitalization and ICU admission of SCD patients diagnosed with COVID-19 through the Northwell Health system from March 1 to Dec 31, 2020. Of 1098 patients with SCD, 3.3% were diagnosed with COVID-19. Overall rates of hospitalization, ICU admission, cohort mortality, and in-hospital mortality were 80%, 19%, 2.5%,and 3.1%, respectively. By multivariable analysis, hospitalization risk was decreased by 60% for every 1 g/dL increase in admission Hb. ICU admission risk was increased by 84% as a health care worker; increased by 45% for every 1000/uL increase in admission immature granulocyte count; and decreased by 17% with hydroxyurea use. High hospitalization rates are compatible with worsened severity upon COVID-19 infection in SCD compared to the general population. Patients should be placed on hydroxyurea to increase their Hb and perhaps lower their neutrophil counts. Health care workers with SCD may warrant special safety precautions.
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DOI：
10.15585/mmwr.mm6943e3
发表时间：
2020-10-30
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
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通讯作者：
COVID-NET Surveillance Team
影响因子：
7.5
作者：
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影响因子：
13.8
作者：
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影响因子：
39.2
作者：
Garg, Shikha;Patel, Kadam;Havers, Fiona P.
通讯作者：
Havers, Fiona P.
DOI：
10.1016/j.ajem.2021.03.083
发表时间：
2021-10
期刊：
The American journal of emergency medicine
影响因子：
--
作者：
Oh SM;Skendelas JP;Macdonald E;Bergamini M;Goel S;Choi J;Segal KR;Vivek K;Nair S;Leff J
通讯作者：
Leff J