New Inspiration of 1,3,4-Oxadiazole Agrochemical Candidates: Manipulation of a Type III Secretion System-Induced Bacterial Starvation Mechanism to Prevent Plant Bacterial Diseases
New Inspiration of 1,3,4-Oxadiazole Agrochemical Candidates: Manipulation of a Type III Secretion System-Induced Bacterial Starvation Mechanism to Prevent Plant Bacterial Diseases
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1,3,4-恶二唑农用化学品候选物的新灵感：操纵III型分泌系统诱导的细菌饥饿机制来预防植物细菌性疾病
DOI：
10.1021/acs.jafc.2c07486
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发表时间：
2023-02-15
影响因子：
6.1
通讯作者：
Yang，Song
中科院分区：
文献类型：
--
作者：
Zeng，Dan;Liu，Shuai-Shuai;Yang，Song
Discovering new anti-virulent agents to control plant bacterial diseases by preventing bacterial pathogenesis/pathogenicity rather than affecting bacterial growth is a sensible strategy. However, the effects of compound-manipulated bacterial virulence factors on host response are still not clear. In this work, 35 new 1,3,4-oxadiazole derivatives were synthesized and systematically evaluated for their anti-phytopathogenic activities. Bioassay results revealed that compoundC7possessed outstanding antibacterial activity in vitro (half-maximal effective concentration: 0.80 μg/mL) againstXanthomonas oryzaepv.oryzae(Xoo) and acceptable bioactivity in vivo toward rice bacterial leaf blight. Furthermore, virulence factor-related biochemical assays showed thatC7was a promising anti-virulent agent. Interestingly,C7could indirectly reduce the inducible expression of hostSWEETgenes and thereby alleviate nutrient supply in the infection process of phytopathogenic bacteria. Our results highlight the potential of 1,3,4-oxadiazole-based agrochemicals for manipulating type III secretion system-induced phytopathogenic bacteria starvation mechanisms to prevent plant bacterial diseases.
