Using mental imagery to improve memory in patients with Alzheimer disease: trouble generating or remembering the mind's eye?
Using mental imagery to improve memory in patients with Alzheimer disease: trouble generating or remembering the mind's eye?
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DOI：
10.1097/wad.0b013e31822e0f73
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发表时间：
2012-04
影响因子：
2.1
通讯作者：
Ally BA
中科院分区：
文献类型：
--
作者：
Hussey EP;Smolinsky JG;Piryatinsky I;Budson AE;Ally BA
本研究旨在了解轻度阿尔茨海默病(AD)患者是否可以使用一般或自我参照心理意象来提高他们对视觉呈现的单词的识别能力。实验一表明，与健康对照组不同，患者通常不会从这两种图像中受益。为了帮助确定患者在编码时无法从心理意象中获益是由于记忆力差还是由于心理意象受损，受试者随后执行了四项意象任务，具有不同的意象和认知需求。实验2表明，患者成功地完成了基本的视觉意象，但语义记忆退化，加上视觉空间和执行功能缺陷，削弱了他们执行更复杂类型的意象的能力。鉴于AD患者可以进行基本的心理想象，我们的结果表明，情景记忆缺陷可能会阻止AD患者存储或提取编码过程中产生的一般心理图像。总体而言，这两个实验的结果都表明，神经认知缺陷不允许AD患者进行复杂的心理想象，这可能对改善记忆最有利。然而，我们的数据也表明，如果在康复多阶段干预方法中使用完整的基本心理想象和排练，可能会有所帮助。
The present investigation worked to understand whether patients with mild Alzheimer's disease (AD) could use general or self-referential mental imagery to improve their recognition of visually presented words. Experiment 1 showed that, unlike healthy controls, patients generally did not benefit from either type of imagery. To help determine whether the patients' inability to benefit from mental imagery at encoding was due to poor memory or due to an impairment in mental imagery, subjects then performed four imagery tasks, with varying imagery and cognitive demands. Experiment 2 showed that patients successfully performed basic visual imagery, but degraded semantic memory, coupled with visuospatial and executive functioning deficits, impaired their ability to perform more complex types of imagery. Given that patients with AD can perform basic mental imagery, our results suggest that episodic memory deficits likely prevent AD patients from storing or retrieving general mental images generated during encoding. Overall, the results of both experiments suggest that neurocognitive deficits do not allow patients with AD to perform complex mental imagery, which may be most beneficial to improving memory. However, our data also suggest that intact basic mental imagery and rehearsal could possibly be helpful if used in a rehabilitation multi-session intervention approach.