Declarative memory consolidation in humans:: A prospective functional magnetic resonance imaging study
Declarative memory consolidation in humans:: A prospective functional magnetic resonance imaging study
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DOI：
10.1073/pnas.0507774103
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发表时间：
2006-01-17
影响因子：
11.1
通讯作者：
Fernández, G
中科院分区：
文献类型：
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作者：
Takashima, A;Petersson, KM;Fernández, G
最近获得的陈述性记忆的检索取决于海马体，但随着时间的推移，仅通过新皮质表征就可以越来越可持续地检索。这个过程被概念化为系统级整合。使用功能性磁共振成像，我们在三个月的时间里评估了巩固如何影响记忆检索的神经相关性。初始学习课程之后和第一天第一次扫描课程之前的小睡/休息期间的慢波睡眠持续时间与小睡前学习项目的识别记忆表现呈正相关，而与与正确自信识别相关的海马活动呈负相关。在整个研究过程中，正确自信识别的海马活动持续减少，而腹内侧前额叶区域的活动增加。这些发现，加上在啮齿动物中获得的数据，可能会促使经典巩固理论的修订，将假定的连接节点从海马转移到前边缘前额叶区域。
Retrieval of recently acquired declarative memories depends on the hippocampus, but with time, retrieval is increasingly sustainable by neocortical representations alone. This process has been conceptualized as system-level consolidation. Using functional magnetic resonance imaging, we assessed over the course of three months how consolidation affects the neural correlates of memory retrieval. The duration of slow-wave sleep during a nap/rest period after the initial study session and before the first scan session on day 1 correlated positively with recognition memory performance for items studied before the nap and negatively with hippocampal activity associated with correct confident recognition. Over the course of the entire study, hippocampal activity for correct confident recognition continued to decrease, whereas activity in a ventral medial prefrontal region increased. These findings, together with data obtained in rodents, may prompt a revision of classical consolidation theory, incorporating a transfer of putative linking nodes from hippocampal to prelimbic prefrontal areas.