Metabolic control of food intake and estrous cycles in syrian hamsters. I. Plasma insulin and leptin.
Metabolic control of food intake and estrous cycles in syrian hamsters. I. Plasma insulin and leptin.
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DOI：
10.1152/ajpregu.2000.278.2.r476
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发表时间：
2000-02
期刊：
影响因子：
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通讯作者：
J. E. Schneider;R. M. Blum;G. Wade
中科院分区：
文献类型：
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作者：
J. E. Schneider;R. M. Blum;G. Wade
“脂肪抑制假说”是指循环激素浓度反映身体肥胖水平并充当控制食物摄入和繁殖的信号。脂肪抑制假说中隐含着以下两个假设：1）脂肪抑制激素的血浆水平准确地反映了体内脂肪含量；2）脂肪抑制激素血浆浓度的降低必然导致食物摄入量增加并抑制生殖过程。本实验旨在检验这些假设。肥胖和瘦的叙利亚仓鼠要么禁食 12、24、36 或 48 小时，要么允许随意进食。与第一个假设相反，肥胖仓鼠的血浆瘦素和胰岛素水平在禁食开始12小时后急剧下降，体脂含量没有显着变化，也没有禁食后食欲亢进。瘦仓鼠在禁食 48 小时后表现出不发情，但在 24 小时禁食后则没有。与脂肪抑制假说的第二个假设相反，瘦仓鼠禁食 24 小时，然后在接下来的 24 小时重新进食，其瘦素水平与禁食 48 小时的仓鼠相比并没有显着升高。因此，在成年雌性叙利亚仓鼠中，血浆瘦素浓度并不能准确反映所有条件下的身体脂肪含量；正常的动情周期并不一定需要比禁食仓鼠更高的血浆瘦素浓度；血浆瘦素水平降低不会导致食物摄入量增加。
The "adipostat hypothesis" refers to the idea that circulating hormone concentrations reflect levels of body adiposity and act as signals to control food intake and reproduction. Implicit in the adipostatic hypothesis are the following two assumptions: 1) plasma levels of adipostatic hormones accurately reflect body fat content and 2) decreased plasma concentrations of adipostatic hormones necessarily result in increased food intake and inhibited reproductive processes. The present experiments are designed to test these assumptions. Fat and lean Syrian hamsters were either fasted for 12, 24, 36, or 48 h or allowed ad libitum access to food. Contrary to the first assumption, plasma leptin and insulin levels in fat hamsters dropped dramatically by 12 h after the start of a fast, with no significant change in body fat content and no postfast hyperphagia. Lean hamsters showed anestrus after a 48-h fast but not after a 24-h fast. Contrary to the second assumption of the lipostatic hypothesis, lean hamsters fasted for 24 h and then refed for the next 24 h had leptin levels that were not significantly elevated compared with those of 48-h-fasted hamsters. Thus, in adult female Syrian hamsters, plasma leptin concentrations do not accurately reflect body fat content under all conditions; normal estrous cyclicity does not necessarily require plasma leptin concentrations higher than those of fasted hamsters; and decreased plasma leptin levels do not result in increased food intake.