White matter integrity is reduced in bulimia nervosa.
White matter integrity is reduced in bulimia nervosa.
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神经性贪食症的白质完整性降低。
DOI：
10.1002/eat.22083
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Frank,GuidoKW
中科院分区：
文献类型：
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作者：
Mettler,LisaN;Shott,MeganE;Pryor,Tamara;Yang,TonyT;Frank,GuidoKW
目的探讨神经性贪食症（BN）患者脑白色物质（WM）功能与焦虑的关系。（CW，平均年龄27 ± 7岁）和20名BN女性（平均年龄25 ± 5岁）进行脑扩散张量成像，以测量各向异性分数（FA; WM轴突完整性的指示）和表观扩散系数结果双侧放射冠延伸至内囊后肢、胼胝体、右岛下WM和右穹窿的BN中FA降低。在CW，而不是BN，特质焦虑与穹窿，胼胝体，左冠状辐射FA呈负相关。双侧放射冠、胼胝体、额枕下部和钩束的BN ADC值高于CW。BN WM功能的改变不是由于结构脑alterations.DiscussionWM的完整性在BN中受到干扰，特别是在辐射冠，这已与味觉和大脑奖励处理。这是一种病前状态还是疾病的影响尚不确定。WM FA和特质焦虑之间的关系在CW，但不是BN可能表明，改变WM功能有助于高焦虑特质BN。© 2013由Wiley Periodicals，Inc. (Int J Eat Disord 2013）
ObjectiveTo investigate brain white matter (WM) functionality in bulimia nervosa (BN) in relation to anxiety.MethodTwenty‐one control women (CW, mean age 27 ± 7 years) and 20 BN women (mean age 25 ± 5 years) underwent brain diffusion tensor imaging to measure fractional anisotropy (FA; an indication of WM axon integrity) and the apparent diffusion coefficient (ADC; reflecting WM cell damage).ResultsFA was decreased in BN in the bilateral corona radiata extending into the posterior limb of the internal capsule, the corpus callosum, the right sub‐insular WM, and right fornix. In CW but not BN, trait anxiety correlated negatively with fornix, corpus callosum, and left corona radiata FA. ADC was increased in BN compared with CW in the bilateral corona radiata, corpus callosum, inferior fronto‐occipital, and uncinate fasciculus. Alterations in BN WM functionality were not due to structural brain alterations.DiscussionWM integrity is disturbed in BN, especially in the corona radiata, which has been associated with taste and brain reward processing. Whether this is a premorbid condition or an effect from the illness is yet uncertain. The relationships between WM FA and trait anxiety in CW but not BN may suggest that altered WM functionality contributes to high anxious traits in BN. © 2013 by Wiley Periodicals,Inc. (Int J Eat Disord 2013)