Mitochondrial subversion in cancer.
Mitochondrial subversion in cancer.
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DOI：
10.1158/1940-6207.capr-10-0326
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Sidransky D
中科院分区：
文献类型：
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作者：
Chatterjee A;Dasgupta S;Sidransky D
线粒体控制基本的细胞活动，包括通过氧化磷酸化产生ATP。线粒体DNA（mtDNA）调控D环区突变和体细胞mtDNA突变在原发性人类癌症中很常见。给定突变的生物学影响可能会有所不同，这取决于突变的性质和细胞携带的突变mtDNA的比例。癌前病变中mtDNA突变的鉴定支持它们对细胞转化和癌症进展的早期贡献。在转化细胞中引入mtDNA突变与增加的ROS产生和肿瘤生长相关。研究表明，线粒体DNA的增加和改变在癌症的发展中起作用，但需要进一步的工作来确定特定线粒体突变在癌症和疾病进展中的功能意义。本文综述了线粒体DNA突变的程度、其在肿瘤发生、线粒体治疗和未来临床应用中的功能后果。
Mitochondria control essential cellular activities including generation of ATP via oxidative phosphorylation. Mitochondrial DNA (mtDNA) mutations in the regulatory D-loop region and somatic mtDNA mutations are common in primary human cancers. The biological impact of a given mutation may vary, depending on the nature of the mutation and the proportion of mutant mtDNAs carried by the cell. Identification of mtDNA mutations in precancerous lesions supports their early contribution to cell transformation and cancer progression. Introduction of mtDNA mutations in transformed cells has been associated with increased ROS production and tumor growth. Studies reveal that increased and altered mtDNA plays a role in the development of cancer but further work is required to establish the functional significance of specific mitochondrial mutations in cancer and disease progression. This review offers some insight into the extent of mtDNA mutations, their functional consequences in tumorigenesis, mitochondrial therapeutics, and future clinical application.