Temperature Responsive Gels Based on Pluronic F127 and Poly(vinyl alcohol)
Temperature Responsive Gels Based on Pluronic F127 and Poly(vinyl alcohol)
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DOI：
10.1021/ie1024408
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发表时间：
2011-04-06
影响因子：
4.2
通讯作者：
Morariu, Simona
中科院分区：
文献类型：
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作者：
Bercea, Maria;Darie, Raluca Nicoleta;Morariu, Simona
制备Pluronic F127和聚（乙烯醇）（系统中聚合物浓度为20%）的水性混合物，并通过流变学和激光粒度分布进行研究，以获得用于生物医学应用的温度响应性凝胶。考察了凝胶化条件和体系组成对粘弹参数和粒径分布的影响。在生理温度（37 ℃）下实现的研究显示了凝胶的触变性，普朗尼克存在引起的屈服应力，以及蠕变恢复试验中证明的高弹性。
Aqueous mixtures of Pluronic F127 and poly(vinyl alcohol) (20% polymer concentration in the system) were prepared and investigated by rheology and laser particle size distribution, in order to obtain temperature responsive gels for biomedical applications. The influence of the gelation conditions and system composition on the viscoelastic parameters and particle size distribution (which are very sensitive to the sot gel transition process) was followed. The investigations realized at physiological temperature (37 degrees C) showed the thixotropic profile of the gels, the yield stress induced by the Pluronic presence, and the high elasticity evidenced in the creep-recovery tests.