The autism diagnostic observation schedule: Patterns in individuals with anorexia nervosa
The autism diagnostic observation schedule: Patterns in individuals with anorexia nervosa
复制标题
DOI：
10.1002/erv.2757
复制
发表时间：
2020-07-29
影响因子：
5.3
通讯作者：
Tchanturia, Kate
中科院分区：
文献类型：
--
作者：
Bentz, Mette;Westwood, Heather;Tchanturia, Kate
目的已有研究将孤独症诊断观察量表（ADOS-2）应用于神经性厌食症（AN）患者，但其评分模式尚未得到评估。我们检查了ADOS-2项目的哪个子集最能区分AN患者和健康对照（HC），并根据ADOS-2项目评分的不同特征评估了AN参与者的潜在聚类。方法我们结合了两项先前研究的数据集，（a）比较年轻AN参与者（N= 118）和HC（N= 42）之间的平均排名，（ii）复制现有ADOS-2算法的项目选择程序，以评估AN组中项目的敏感性，（c）在AN组（N= 149）中应用两步聚类分析。结果AN参与者在32个项目中的5个项目中的平均排名显着高于HC参与者。所有五项都是现有ADOS-2算法的一部分。我们发现了两组AN参与者;一组代表正常的社会行为，包括68%的AN患者，另一组代表效率较低的社会行为，包括32%的AN患者。结论现有ADOS-2算法的社会情感聚类项目非常适合评估AN患者的社会功能障碍。
Objective Studies have used the Autism Diagnostic Observation Schedule (the ADOS-2) in individuals with anorexia nervosa (AN), but the patterns of scores have not been assessed. We examined which subset of the ADOS-2 items best discriminate individuals with AN from healthy controls (HC), and assessed the potential clustering of AN participants based on different profiles of the ADOS-2 item scores. Method We combined datasets from two previous studies, and (a) compared mean ranks between young AN participants (N= 118) and HC (N= 42), (ii) replicated the item selection procedure of the existing ADOS-2 algorithm to assess sensitivity of items in the AN group, and (c) applied a two-step clustering analysis in the AN group (N= 149). Results AN participants displayed significantly higher mean ranks than HC participants in five of 32 items. All five items are part of the existing ADOS-2 algorithm. We found two clusters of AN participants; one representing normal social behaviour, comprising 68% of the individuals with AN, and one representing less efficient social behaviour, comprising 32% of individuals with AN. Conclusions The items comprising the social affective cluster of the existing ADOS-2 algorithm are well suited to assess difficulties with social functioning in individuals with AN.