SARS-CoV-2 Seroprevalence and Antibody Kinetics Among Health Care Workers in a Spanish Hospital After 3 Months of Follow-up.
SARS-CoV-2 Seroprevalence and Antibody Kinetics Among Health Care Workers in a Spanish Hospital After 3 Months of Follow-up.
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DOI：
10.1093/infdis/jiaa696
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发表时间：
2021-01-04
期刊：
影响因子：
--
通讯作者：
Garcia-Basteiro AL
中科院分区：
文献类型：
--
作者：
Moncunill G;Mayor A;Santano R;Jiménez A;Vidal M;Tortajada M;Sanz S;Méndez S;Llupià A;Aguilar R;Alonso S;Barrios D;Carolis C;Cisteró P;Chóliz E;Cruz A;Fochs S;Jairoce C;Hecht J;Lamoglia M;Martínez MJ;Moreno J;Mitchell RA;Ortega N;Pey N;Puyol L;Ribes M;Rosell N;Figueroa-Romero A;Sotomayor P;Torres S;Williams S;Barroso S;Vilella A;Trilla A;Varela P;Dobaño C;Garcia-Basteiro AL
在西班牙2020年春季COVID-19大流行高峰期，从巴塞罗那医院随机选择的578名医护人员（HCW）中的SARS-CoV-2感染率为11. 2%。1个月后（2020年4月至5月）的随访调查通过rRT-PCR和Luminex对刺突蛋白受体结合结构域的IgM、伊加和IgG进行了测量。评估抗体动力学，包括IgG亚类，直至第3个月。在第1个月，通过rRT-PCR和血清学测量的感染率为14.9%（84/565），血清阳性率为14.5%（82/565）。我们在501名参与者中发现了25例（5%）新感染，以前没有感染证据。IgM、IgG和伊加水平在3个月内下降（抗体衰减率分别为0.15 [95%CI，0.11 - 0.19]、0.66 [95%CI，0.54 - 0.82]和0.12 [95%CI，0.09 - 0.16]），68.33%的HCW发生IgM血清逆转，3.08%发生IgG血清逆转，24.29%发生伊加血清逆转。最常见的亚类应答为IgG 1（最高水平）和IgG 2，其次为IgG 3，仅检测到IgA 1，未检测到IgA 2。对医务工作者中SARS-CoV-2感染的持续和改进的监测仍然至关重要，特别是在高风险群体中。所观察到的伊加和IgM水平的快速衰减对使用这些同种型的血清阳性率研究具有影响。578名医护人员的SARS-CoV-2患病率从COVID-19大流行高峰时的11.2%上升至1个月后的14.9%。IgM、IgG和伊加水平在3个月的随访中分别下降了68.33%、3.08%和24.29%。
At the COVID-19 spring 2020 pandemic peak in Spain, prevalence of SARS-CoV-2 infection in a cohort of 578 randomly selected health care workers (HCWs) from Hospital Clínic de Barcelona was 11.2%. A follow-up survey 1 month later (April-May 2020) measured infection by rRT-PCR and IgM, IgA, and IgG to the receptor-binding domain of the spike protein by Luminex. Antibody kinetics, including IgG subclasses, was assessed until month 3. At month 1, the prevalence of infection measured by rRT-PCR and serology was 14.9% (84/565) and seroprevalence 14.5% (82/565). We found 25 (5%) new infections in 501 participants without previous evidence of infection. IgM, IgG, and IgA levels declined in 3 months (antibody decay rates 0.15 [95% CI, .11–.19], 0.66 [95% CI, .54–.82], and 0.12 [95% CI, .09–.16], respectively), and 68.33% of HCWs had seroreverted for IgM, 3.08% for IgG, and 24.29% for IgA. The most frequent subclass responses were IgG1 (highest levels) and IgG2, followed by IgG3, and only IgA1 but no IgA2 was detected. Continuous and improved surveillance of SARS-CoV-2 infections in HCWs remains critical, particularly in high-risk groups. The observed fast decay of IgA and IgM levels has implications for seroprevalence studies using these isotypes. SARS-CoV-2 prevalence in 578 health care workers increased from 11.2% at the COVID-19 pandemic peak to 14.9% 1 month later. IgM, IgG, and IgA levels declined over 3 months of follow-up with 68.33%, 3.08%, and 24.29% of seroreversions, respectively.
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