Serum and Middle Ear Immunoglobulins in Suppurative Otitis Media
Serum and Middle Ear Immunoglobulins in Suppurative Otitis Media
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DOI：
10.1159/000163035
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发表时间：
2008-01-01
期刊：
影响因子：
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通讯作者：
Bakare, Rasheed A.
中科院分区：
文献类型：
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作者：
Lasisi, Akeem O.;Arinola, Olatubosun G.;Bakare, Rasheed A.
背景和目的：尽管化脓性中耳炎（SOM）的发生率越来越高，但中耳分泌物（MES）中免疫球蛋白组分的含量仍然没有确定。方法：采用酶联免疫法检测血清和MES中IgG和M。结果：研究对象为男性30例，女性22例，年龄6个月~ 9岁，平均6岁（SD = 3.26）。其中慢性SOM（CSOM）20例，急性SOM（ASOM）17例，对照组15例。对照组的平均血清IgG水平为1，051 mg/dl，ASOM为666.1 mg/dl，CSOM为1，321.1 mg/dl; ASOM和CSOM的MES水平为203.4 mg/dl和511.5 mg/dl。对照组的平均血清IgM水平为35 mg/dl，ASOM为64.1 mg/dl，CSOM为40 mg/dl; MES水平为ASOM为22.59 mg/dl，CSOM为3.44 mg/dl。平均MES：IgG和IgM的血清比率在ASOM和CSOM中为0.1和0.4之间。对照组与ASOM患者血清IgG水平比值为0.66，对照组与CSOM患者血清IgG水平比值为1.3。IgM的相应比值为1.6和0.88。多因素分析显示ASOM和CSOM的血清IgG水平之间存在显著相关性（p = 0.043）和MES IgG（p = 0.02），但对照组和ASOM组血清IgG水平之间无相关性（p = 0.25），对照组和CSOM组的血清IgM水平（p = 0.62）和对照和ASOM（p = 0.73）、ASOM和CSOM（p = 0.064）中的血清IgM水平以及ASOM和CSOM的MES IgM水平（p = 0.06）。结论：监测ASOM患者血清及MES IgG水平可作为判断ASOM进展为慢性的一个有用指标。这形成了SOM患者免疫状态的数据库。版权所有（C）2008 S. Karger AG，巴塞尔
Background and Purpose: Despite the increasing occurrence of suppurative otitis media (SOM), the content of immunoglobulin fractions in the middle ear secretion (MES) has still not been determined. Method: The serum and MES were analyzed for IgG and M using enzyme-linked immuno-assay. Result: The subjects and controls were 30 males and 22 females, between 6 months and 9 years old, with a mean age of 6 years (SD = 3.26). The patient group included 20 chronic SOM (CSOM) and 17 acute SOM (ASOM) cases, and sera of 15 subjects made the control group. The mean serum IgG levels were for controls 1,051 mg/dl, ASOM 666.1 mg/dl and CSOM 1,321.1 mg/dl; the MES levels were for ASOM 203.4 mg/dl and CSOM 511.5 mg/dl. The mean serum IgM levels were for controls 35 mg/dl, ASOM 64.1 mg/dl and CSOM 40 mg/dl; the MES levels were for ASOM 22.59 mg/dl and CSOM 3.44 mg/dl. The mean MES: serum ratios for IgG and IgM were between 0.1 and 0.4 in ASOM and CSOM. The ratio of serum IgG levels of controls to ASOM cases was 0.66 while that of controls to CSOM was 1.3. The corresponding ratios of IgM were 1.6 and 0.88. Multivariate analysis revealed a significant correlation between serum IgG levels of ASOM and CSOM (p = 0.043) and MES IgG (p = 0.02) in ASOM and CSOM but no correlation between serum IgG levels in controls and ASOM (p = 0.25), serum IgM levels in controls and CSOM (p = 0.62) and serum IgM levels in controls and ASOM (p = 0.73), ASOM and CSOM (p = 0.064) and MES IgM levels of ASOM and CSOM (p = 0.06). Conclusions: Monitoring of the serum and MES IgG in ASOM may provide a useful index to assess the possibility of progression to chronicity. This forms a database for the immunological status of SOM patients. Copyright (C) 2008 S. Karger AG, Basel