PROBLEMATIC UTERINE SMOOTH-MUSCLE NEOPLASMS - A CLINICOPATHOLOGICAL STUDY OF 213 CASES
PROBLEMATIC UTERINE SMOOTH-MUSCLE NEOPLASMS - A CLINICOPATHOLOGICAL STUDY OF 213 CASES
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DOI：
10.1097/00000478-199406000-00001
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发表时间：
1994-06-01
影响因子：
5.6
通讯作者：
HENDRICKSON, MR
中科院分区：
文献类型：
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作者：
BELL, SW;KEMPSON, RL;HENDRICKSON, MR
子宫平滑肌肿瘤（USMN）临床良性和临床恶性组的分类最近的趋势是从完全依赖有丝分裂指数（MI）的方法，包括其他组织病理学特征。为了进一步实现这一目标，我们评估了213例有问题的平滑肌肿瘤的各种组织病理学特征，这些肿瘤我们有大于或等于2年的临床随访数据，或者有不利的结局。这些患者中有113例至少随访5年，48例随访时间大于或等于10年。从研究组中排除的病例包括具有显著粘液样或上皮样成分的USMN和静脉内平滑肌瘤病病例。无细胞学异常且有丝分裂指数（MI =有丝分裂像数[mf]/10个高倍视野[hp]l）
A recent trend in the classification of uterine smooth muscle neoplasms (USMNs) into clinically benign and clinically malignant groups has been to move from exclusive reliance upon mitotic index (MI) to an approach that incorporates additional histopathologic characteristics. In furtherance of this goal, we assessed a variety of histopathologic features of 213 problematic smooth muscle neoplasms for which we had greater than or equal to 2 years of clinical followup data or for which there was an unfavorable outcome. One hundred and thirteen of these patients have had a minimum follow-up of 5 years, and 48 have been followed for greater than or equal to 10 years. Cases eliminated from the study group included USMNs with a significant myxoid or epithelioid component and cases of intravenous leiomyomatosis. USMNs, whether cellular or not, with no cytologic atypia and with a mitotic index (MI = number of mitotic figures [mf]/10 high-power fields [hp]l) of