Natural killer cell activity in patients with adenocarcinoma in the upper gastrointestinal tract.
Natural killer cell activity in patients with adenocarcinoma in the upper gastrointestinal tract.
复制标题
上消化道腺癌患者的自然杀伤细胞活性。
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
C. Lamers
中科院分区：
文献类型：
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作者：
M. N. Aparicio;H. Verspaget;A. Peña;C. Lamers
自然杀伤（NK）细胞活性和重组γ-干扰素（γ-IFN）的体外效果进行了评估，在12例食管腺癌，14例胃腺癌，12例胰腺癌患者，和19名健康对照对红白血病细胞系K-562。上消化道癌患者的自然NK细胞活性与对照组相似。经γ-IFN刺激后，食管癌和胰腺癌患者的NK细胞活性明显低于胃癌患者和对照组（P <0.05）。当所有腺癌患者根据疾病的进展进行分类时，发现与局部疾病患者或对照组相比，晚期疾病患者的NK细胞活性明显受损（p <0.01）。虽然γ-干扰素刺激患者和对照组的NK细胞活性显着，62%的癌症和晚期疾病的患者仍然低于正常的自发NK细胞活性水平，即使在γ-干扰素刺激。总之，在食管癌或胰腺癌患者中发现NK细胞活性受损。晚期疾病患者比局限性疾病患者更可能具有受损的NK细胞活性。NK细胞活性降低，特别是食管癌或胰腺癌患者的NK细胞活性降低，可能与这些患者的不良预后有关。
Natural killer (NK) cell activity and the in vitro effect of recombinant gamma interferon (r gamma-IFN) were evaluated in 12 patients with esophageal adenocarcinoma, 14 patients with gastric adenocarcinoma, 12 patients with pancreatic adenocarcinoma, and 19 healthy controls against the erythroleukemia cell line K-562. Patients with upper gastrointestinal tract carcinomas had a similar spontaneous NK cell activity as the control group. After stimulation with r gamma-IFN, however, the NK cell activity of patients with esophageal or pancreatic adenocarcinoma was significantly lower than that of patients with gastric carcinoma and that of the controls (p less than 0.05). When all patients with adenocarcinomas were classified according to the advancement of the disease, a marked impairment of NK cell activity was found in patients with advanced disease (p less than 0.01) compared to the patients with localized disease or to the controls. Although r gamma-IFN stimulated the NK cell activity of both patients and controls significantly, 62% of the patients with carcinoma and advanced disease remained below the normal spontaneous NK cell activity level even after r gamma-IFN stimulation. In conclusion, an impaired NK cell activity was found in patients with esophageal or pancreatic cancer. Patients with advanced disease were more likely to have an impaired NK cell activity than those with localized disease. The decreased NK cell activity, in particular of patients with esophageal or pancreatic carcinoma, may be related to the unfavourable prognosis of these patients.