EVIDENCE SUPPORTING MEMORY DISRUPTION HYPOTHESIS OF ELECTRO-CONVULSIVE SHOCK ACTION
EVIDENCE SUPPORTING MEMORY DISRUPTION HYPOTHESIS OF ELECTRO-CONVULSIVE SHOCK ACTION
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DOI：
10.1016/0031-9384(69)90037-7
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发表时间：
1969-01-01
影响因子：
2.9
通讯作者：
PAGANO, R
中科院分区：
文献类型：
--
作者：
BANKER, G;HUNT, E;PAGANO, R
已知训练后的电休克（ECS）会破坏被动回避任务的表现。这种效应通常被认为是ECS产生逆行性遗忘的证据。最近有报道称，如果被动回避训练后几小时进行第二次足电击（FS），然后进行ECS，则在随后的测试中显示出回避受损。这被解释为表明训练-ECS间隔并不重要，因此质疑逆行性遗忘假说。然而，我们重复的双足电击研究未能复制这些观察结果。我们确实注意到第二次FS使动物过度活跃，这表明这不是被动回避研究的适当程序。然后，我们使用了双足电击范式的情况下，涉及被动回避和歧视性回避。实验动物移动得更快，但在选择行为中没有表现出健忘症。ECS在训练后数秒内进行时，观察到痉挛。这一结果与逆行性遗忘假说雅阁。
Electroconvulsive shock (ECS) following training is known to disrupt performance on passive avoidance tasks. The effect is usually seen as evidence that ECS produces retrograde amnesia. Recently it was reported that if passive avoidance training was followed by a second footshock (FS) several hours after training, and then ECS, impaired avoidance was shown on subsequent testing. This was interpreted as showing that the training-ECS interval is not crucial, thus questioning the retrograde amnesia hypothesis. Our repetition of the double foot-shock studies, however, failed to replicate these observations. We did notice that the second FS made animals hyperactive, suggesting that this is not an appropriate procedure in passive avoidance studies. We then used a double foot-shock paradigm in a situation involving both passive avoidance and discriminated avoidance. The experimental animals moved more rapidly, but displayed no amnesia in their choice behavior. Amnesia was observed when ECS followed seconds after training. The results are in accord with the retrograde amnesia hypothesis.