Intrinsic inhibitory pathways in mouse barrel cortex
Intrinsic inhibitory pathways in mouse barrel cortex
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DOI：
10.1097/00001756-199610020-00017
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发表时间：
1996-10-02
期刊：
影响因子：
1.7
通讯作者：
Keller, A
中科院分区：
文献类型：
--
作者：
AroniadouAnderjaska, V;Keller, A
本文用神经束示踪和免疫细胞化学相结合的方法研究了小鼠躯体感觉皮层内神经联系的组织结构。将HRP或荧光珠注射到后内侧桶子域的颗粒上或颗粒下层。在以每个注射部位为中心的垂直柱内逆行标记许多细胞。逆行标记的细胞也仅见于水平于注射处> 3mm处。双标记免疫细胞化学鉴定了形成内在水平连接的抑制性GABA能细胞群。双标记细胞主要发现在200 μ m半径内水平注射部位。这些研究结果表明，在桶皮质的内在抑制途径不提供一个基板桶柱之间的直接GABA能相互作用，柱间的相互作用主要是兴奋性的。
THE organization of intrinsic connections in the mouse somatosensory cortex was studied by combining tract-tracing and immunocytochemical techniques. Injections of HRP or fluorescent beads were made into the supragranular or infragranular layers of the posteriomedial barrel subfield. Numerous cells were retrogradely labeled within a vertical column centered on each injection site. Retrogradely labeled cells mere also found > 3 mm horizontal to the injection. Dual-label immunocytochemistry identified the population of inhibitory, GABAergic cells forming intrinsic horizontal connections. Double-labeled cells were found predominantly within a 200 mu m radius horizontal to an injection site. These findings indicate that intrinsic inhibitory pathways in the barrel cortex do not provide a substrate for direct GABAergic interactions among barrel columns, and that intercolumnar interactions are primarily excitatory.