Effect of a hypolipidemic drug, di (2-ethylhexyl) phthalate, on mRNA-expression associated fatty acid and acetate metabolism in rat tissues
Effect of a hypolipidemic drug, di (2-ethylhexyl) phthalate, on mRNA-expression associated fatty acid and acetate metabolism in rat tissues
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DOI：
10.1271/bbb.60478
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发表时间：
2007-02-01
影响因子：
1.6
通讯作者：
Yamashita, Hiromi
中科院分区：
文献类型：
--
作者：
Itsuki-Yoneda, Ai;Kimoto, Masumi;Yamashita, Hiromi
邻苯二甲酸二(2-乙基己基)酯(DEHP)是一种过氧化物酶体增殖剂，也是一种具有降血脂作用的药物。用 DEHP 治疗的大鼠的体重变化低于未治疗对照组的大鼠。参与线粒体中脂肪酸氧化和乙酸形成的长链酰基辅酶A脱氢酶和3-酮酰基辅酶A硫解酶的表达在用DEHP治疗的大鼠的肝脏和睾丸中有所增加。睾丸中乙酰辅酶A合成酶I的表达显着降低，肝脏中乙酰辅酶A合成酶2的表达相对降低，而心脏中乙酰辅酶A合成酶2的表达显着升高。此外，心脏和睾丸中乙酰辅酶A羧化酶的表达呈下降趋势。这些结果表明，DEHP 处理增加了肝脏和睾丸中的脂肪酸氧化和乙酸盐形成，并且增加了心脏等周围组织中的乙酸盐利用率。
Di (2-ehtylhexyl) phthalate (DEHP) is a peroxisome proliferator and a drug having a hypolipidemic effect. The body-weight change of rats treated with DEHP was lower than that of rats in an untreated control group. Expressions of long-chain acyl-CoA dehydrogenase and 3-ketoacyl-CoA thiolase, which are involved in fatty acid oxidation and acetate formation in mitochondria, showed an increase in the liver and testes of rats treated with DEHP. The expression of acetyl-CoA synthetase I was significantly decreased in the testes and relatively decreased in the liver, while the expression of acetylCoA synthetase 2 was significantly increased in the heart. Furthermore, the expressions of acetyl-CoA carboxylase in heart and testes showed a tendency to decrease. From these results, it is suggested that DEHP-treatment increased fatty acid oxidation and acetate formation in liver and testes, and that acetate utilization was increased in peripheral tissues such as the heart.