PLAQUE FISSURES IN HUMAN CORONARY THROMBOSIS
PLAQUE FISSURES IN HUMAN CORONARY THROMBOSIS
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DOI：
10.1016/s0368-1319(66)80056-x
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发表时间：
1966-01-01
期刊：
影响因子：
--
通讯作者：
CONSTANTINIDES, P
中科院分区：
文献类型：
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作者：
CONSTANTINIDES, P
对连续20例致死性冠状动脉血栓形成的冠状动脉段进行完整的连续切片研究显示，在每个病例中，血栓都被锚定在周围动脉粥样斑块的裂隙中。大多数伴随的斑块出血可以追溯到血液从管腔通过动脉粥样硬化动脉壁的相同或其他裂缝进入，尽管其中一些也是由斑块毛细血管破裂引起的。16例无血栓形成的动脉粥样硬化冠状动脉壁未见裂缝。这些发现表明，动脉粥样硬化的冠状动脉脆性内膜的突然破裂是导致人类冠状动脉血栓形成的一个主要因素。
Complete serial section study of the thrombosed segments of the coronary arteries from 20 consecutive case of fatal coronary thrombosis revealed that in each instance the thrombus was anchored in fissures of the surrounding atheromatous plaques. Most of the accompanying plaque hemorrhages could be traced to an entry of blood from the lumen through the same or other cracks in the atherosclerotic artery wall, although some of them also resulted from the rupture of plaque capillaries. There were no cracks in the wall of 16 atherosclerotic coronaries without thrombosis that were studied in the same manner. These findings suggest that the sudden break of the brittle lining of atherosclerotic coronary arteries represents a major factor in the causation of human coronary thrombosis.