Multiparametric detection of autoantibodies in systemic lupus erythematosus
Multiparametric detection of autoantibodies in systemic lupus erythematosus
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DOI：
10.1177/0961203316641770
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发表时间：
2016-07-01
期刊：
影响因子：
2.6
通讯作者：
Schneider, M.
中科院分区：
文献类型：
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作者：
Budde, P.;Zucht, H-D;Schneider, M.
系统性红斑狼疮 (SLE) 是一种在疾病表现、疾病进展和治疗反应方面具有异质性的疾病。因此，识别有助于区分 SLE 亚组的生物标志物的策略是生物标志物研究的主要焦点。我们推断，多参数自身抗体分析方法与数据挖掘工具相结合可用于识别 SLE 患者群。我们使用基于珠子的阵列，包含 86 种抗原，包括多种核和免疫防御途径蛋白。 64 种自身抗体显着 (p
Systemic lupus erythematosus (SLE) is a heterogeneous disease with respect to disease manifestations, disease progression and treatment response. Therefore, strategies to identify biomarkers that help distinguishing SLE subgroups are a major focus of biomarker research. We reasoned that a multiparametric autoantibody profiling approach combined with data mining tools could be applied to identify SLE patient clusters. We used a bead-based array containing 86 antigens including diverse nuclear and immune defense pathway proteins. Sixty-four autoantibodies were significantly (p