Arrhythmogenic right ventricular cardiomyopathy and fatty replacement of the right ventricular myocardium - Are they different diseases?
Arrhythmogenic right ventricular cardiomyopathy and fatty replacement of the right ventricular myocardium - Are they different diseases?
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DOI：
10.1161/01.cir.97.16.1571
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发表时间：
1998-04-28
期刊：
影响因子：
37.8
通讯作者：
Virmani, R
中科院分区：
文献类型：
--
作者：
Burke, AP;Farb, A;Virmani, R
方法和结果：在25例典型的右室心肌病（ARVC）患者的16个切片中测量心肌厚度、心外膜脂肪厚度、纤维化百分比和心肌内脂肪浸润，（纤维脂肪）ARVC，7个心脏与右心室脂肪替代无纤维化（FaRV），和18个对照心脏的患者死于非心脏原因。纤维脂肪ARVC患者比FaRV患者年轻（31 +/- 14 vs 44 +/- 13岁，P=.02），更可能有心律失常史或过早猝死家族史（56% vs 0%，P=.01），男性更有可能（80%对29%，P= 0.02），并且不太可能有可能导致猝死的共存条件（12%对86%，P
Background-The relationship between arrhythmogenic right ventricular cardiomyopathy (ARVC) and pure fat replacement of the right ventricle is unclear.Methods and Results-Myocardial thickness, epicardial fat thickness, percent fibrosis, and intramyocardial fat infiltration were measured in 16 sections each from 25 hearts with typical (fibrofatty) ARVC, 7 hearts with fat replacement of the right ventricle without fibrosis (FaRV), and 18 control hearts from patients who died of noncardiac causes. Patients with fibrofatty ARVC were younger than those with FaRV (31 +/- 14 versus 44 +/- 13 years, P=.02), more Likely to have a history of arrhythmias or a family history of premature sudden death (56% versus 0%, P=.01), more likely male (80% versus 29%, P=.02), and less likely to have coexisting conditions that might have predisposed to sudden death (12% versus 86%, P