The role of the medial wall and its anatomical variations for bimanual antiphase and in-phase movements
The role of the medial wall and its anatomical variations for bimanual antiphase and in-phase movements
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DOI：
10.1006/nimg.2001.0856
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发表时间：
2001-09-01
期刊：
影响因子：
5.7
通讯作者：
Hallett, M
中科院分区：
文献类型：
--
作者：
Immisch, I;Waldvogel, D;Hallett, M
额叶皮层内侧壁被认为对双手协调起着重要作用。然而，涉及的确切神经解剖区域尚不确定。我们比较了激活模式相关的双手运动功能磁共振成像在12个健康的右利手的主题，特别注意的解剖变异的额内侧壁。受试者进行单手右，左和双手反相和同相屈曲和食指伸展运动。右辅助运动区（SMA）适当的，右和左尾扣带运动区（CMA），右和左运动前皮质的激活显着强于双手反相比双手同相运动，表明这些领域的重要功能与双手协调。一个常见的解剖变异是存在的副扣带沟（PCS），这可能是一个解剖标志，以确定激活区的位置。7例受试者有双侧PCS，3例单侧右侧PCS，2例单侧左侧PCS。由于PCS周围区域在功能上与CMA的耦合比与SMA的耦合更紧密，因此在PCS周围区域发现的激活应归因于CMA。由于解剖学变异，例如存在PCS或扣带回沟的垂直分支，在立体定位坐标的帮助下对激活进行标准化和确定可能导致CMA激活不正确地转移到SMA。这可能解释了以前研究中发现的一些差异。
The medial wall of the frontal cortex is thought to play an important role for bimanual coordination. However, there is uncertainty regarding the exact neuroanatomical regions involved. We compared the activation patterns related to bimanual movements using functional magnetic resonance imaging in 12 healthy right-handed subjects, paying special attention to the anatomical variability of the frontal medial wall. The subjects performed unimanual right and left and bimanual antiphase and in-phase flexion and extension movements of the index finger. Activation of the right supplementary motor area (SMA) proper, right and left caudal cingulate motor area (CMA), and right and left premotor cortices was significantly stronger during bimanual antiphase than bimanual in-phase movements, indicating an important function of these areas with bimanual coordination. A frequent anatomical variation is the presence of the paracingulate sulcus (PCS), which might be an anatomical landmark to determine the location of activated areas. Seven subjects had a bilateral, three a unilateral right, and two a unilateral left PCS. Because the area around the PCS is functionally closer coupled to the CMA than to the SMA, activation found in the area around the PCS should be attributed to the CMA. With anatomical variations such as the presence of a PCS or a vertical branch of the cingulate sulcus, normalization and determination of the activation with the help of stereotaxic coordinates can cause an incorrect shift of CMA activation to the SMA. This might explain some of the discrepancies found in previous studies.