Ethnicity and persistent symptom burden in breast cancer survivors.
Ethnicity and persistent symptom burden in breast cancer survivors.
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DOI：
10.1007/s11764-009-0100-7
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发表时间：
2009-12
期刊：
影响因子：
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通讯作者：
Hershman DL
中科院分区：
文献类型：
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作者：
Fu OS;Crew KD;Jacobson JS;Greenlee H;Yu G;Campbell J;Ortiz Y;Hershman DL
对乳腺癌幸存者的研究相对较少，包括非白人女性或不会说英语的女性。我们对哥伦比亚大学医学中心完成 0-III 期乳腺癌辅助治疗 3 个月以上的患者进行了一项调查，以评估 16 种身体和情绪症状的患病率，并确定与这些症状相关的社会人口学因素。进行单变量分析、因子分析、方差分析和多元线性回归分析。在接受调查的 139 名患者中，58 名是白人，63 名是西班牙裔，18 名是黑人。最常见的症状是疲劳（76%），最常见的严重症状是肌肉酸痛（40%）。大多数患者（70%）抱怨有≥6种症状。西班牙裔女性更有可能报告 >10 种症状 (p<0.05)。因子分析将 16 种症状减少为 4 个潜在症状群，我们将其归类为“抑郁”、“化疗”、“激素”和“疼痛”相关。在多元线性回归模型中，西班牙裔女性更有可能报告化疗相关症状（p<0.05）和疼痛相关症状（p<0.05）。失业女性更有可能报告化疗相关症状（p<0.05）。 <45 岁的女性报告化疗 (p<0.05) 和疼痛相关症状 (p<0.05) 的可能性较小。这项研究中的大多数女性，尤其是西班牙裔、老年人或失业女性，都经历了持续的症状，最常见的是疲劳和肌肉疼痛。由于西班牙裔、老年或失业女性的症状负担更大，因此应努力满足她们的独特需求。
Relatively few studies of breast cancer survivors have included nonwhite women or women who do not speak English. We administered a survey to patients who were ≥3 months post-completion of their adjuvant treatment for stage 0–III breast cancer at Columbia University Medical Center in order to assess the prevalence of 16 physical and emotional symptoms and identify sociodemographic factors associated with these symptoms. Univariate analysis, factor analysis, ANOVA, and multiple linear regression analysis were performed. Of 139 patients surveyed, 58 were white, 63 Hispanic, and 18 black. The symptom most commonly reported was fatigue(76%), and the most common severe symptom was muscle aches(40%). Most patients(70%) complained of ≥6 symptoms. Hispanic women were more likely to report >10 symptoms (p<0.05). Factor analysis reduced the 16 symptoms to 4 underlying symptom clusters that we categorized as ‘depression’, ‘chemotherapy’, ‘hormone’, and ‘pain’-related. In the multiple linear regression models, Hispanic women were more likely to report chemotherapy-related symptoms (p<0.05) and pain-related symptoms (p<0.05). Unemployed women were more likely to report chemotherapy-related symptoms (p<0.05). Women <45 years old were less likely to report chemotherapy (p<0.05) and pain-related symptoms (p<0.05). The majority of women in this study, particularly those who were Hispanic, elderly, or unemployed, experienced persistent symptoms, most commonly fatigue and muscle aches. Because Hispanic, elderly, or unemployed women experience greater symptom burden, efforts should made to address their unique needs.