Design of a New Somatosensory Stimulus Delivery Device for Measuring Laryngeal Mechanosensory Detection Thresholds in Humans
Design of a New Somatosensory Stimulus Delivery Device for Measuring Laryngeal Mechanosensory Detection Thresholds in Humans
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DOI：
10.1109/tbme.2008.2007968
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发表时间：
2009-04-01
影响因子：
4.6
通讯作者：
Hammer, Michael J.
中科院分区：
文献类型：
--
作者：
Hammer, Michael J.
喉控制对于气道保护、呼吸、吞咽、言语和声音是必不可少的。不幸的是，喉感觉评估在研究和临床实践中的整合受到商业可用技术的技术和实践限制的限制。市售器械可用，但报告的局限性包括需要两个或三个人操作的程序复杂性、有限的刺激动态范围、器械产生的噪声和可疑的刺激再现性。本研究的目的是设计一种新的喉体感刺激传递装置，提供直接，可靠的控制的时间，持续时间和动态范围的刺激介绍，并测试设备的个人谁可能表现出喉感觉缺陷。新设备运行安静，刺激动态范围比商业设备大四倍以上。使用新设备进行的测试显示，帕金森病患者的喉部机械感觉检测阈值是健康对照组的7倍。由于商业设备中有限的刺激动态范围，这些数据本来不会被检测到。新设计产生了一种新的评估工具，该工具易于用于常规临床评估，但对于严格的临床研究方案中的集成来说，它具有足够的通用性。
Laryngeal control is essential for airway protection, breathing, deglutition, speech, and voice. Unfortunately, integration of laryngeal sensory assessment in research and clinical practice is limited by technical and practical limitations of commercially available technology. A commercial device is available, but reported limitations include procedural complexity requiring two or three individuals to operate, limited stimulus dynamic range, device generated noise, and questionable stimulus reproducibility. The objective of this study was to design a new laryngeal somatosensory stimulus delivery device that provides direct, reliable control over the timing, duration, and dynamic range of stimulus presentation, and test the device in individuals who may manifest a laryngeal sensory deficit. The new device operates silently and has more than four times greater stimulus dynamic range than the commercial device. Testing with the new device revealed laryngeal mechanosensory detection thresholds in an individual with Parkinson's disease that were seven times higher than those of healthy controls. These data would have otherwise gone undetected due to limited stimulus dynamic range in the commercial device. The new design resulted in a new assessment instrument that is simple to use for routine clinical assessment, yet sufficiently versatile for integration within rigorous clinical research protocols.