Analgesic effects of nonsteroidal antiinflammatory drugs, acetaminophen, and morphine in a mouse model of bone cancer pain.
Analgesic effects of nonsteroidal antiinflammatory drugs, acetaminophen, and morphine in a mouse model of bone cancer pain.
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DOI：
10.1007/s00540-005-0323-3
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发表时间：
2005-01-01
影响因子：
2.8
通讯作者：
Yamamoto, Tatsuo
中科院分区：
文献类型：
--
作者：
Saito, Osamu;Aoe, Tomohiko;Yamamoto, Tatsuo
目的：骨转移是癌性疼痛的主要原因之一，并不是所有的骨癌疼痛都能得到有效的治疗。最近，一种骨癌痛的小鼠模型被引入。为了验证非甾体抗炎药对骨癌疼痛的镇痛作用，作者观察了口服环氧合酶-1(COX-1)选择性抑制剂(SC560)、COX-2选择性抑制剂(塞来昔布)和非选择性COX抑制剂(消炎痛)对骨癌疼痛的影响，并与口服对乙酰氨基酚和吗啡的效果进行了比较。结果：口服对乙酰氨基酚、吲哚美辛和吗啡对骨癌疼痛有明显的镇痛作用，而对SC560和塞来昔布的作用不明显。结论：口服消炎痛、对乙酰氨基酚和吗啡能有效地治疗骨癌疼痛，醋氨酚和阿片类药物合用治疗骨癌疼痛具有良好的疗效。
PURPOSE: Bone metastasis is one of the major causes of cancer-related pain, and not all bone cancer pain can be effectively treated. Recently, a mouse model of bone cancer pain was introduced. To test the analgesic effects of nonsteroidal antiinflammatory drugs on bone cancer pain, the authors examined the effects of oral administration of a cyclooxygenase-1 (COX-1) selective inhibitor (SC560), a COX-2 selective inhibitor (celecoxib), and a nonselective COX inhibitor (indomethacin) on bone cancer pain and compared these effects to the effect of orally administered acetaminophen and morphine.METHODS: An animal model of bone cancer pain was induced by injecting osteolytic murine sarcoma cells in the mouse femur. Drugs were administered orally 2 weeks after tumor-cell implantation, and the level of bone cancer pain was assessed 30, 60, 90, 120, and 180 min after drug administration.RESULTS: Oral administration of acetaminophen, indomethacin, and morphine, but not of SC560 or celecoxib, produced an analgesic effect on bone cancer pain. Co-administration of a subanalgesic does of morphine with acetaminophen enhanced the analgesic effect of acetaminophen.CONCLUSION: These data suggest that bone cancer pain is effectively treated by oral administration of indomethacin, acetaminophen, and morphine and that the co-administration of acetaminophen and an opioid provides a beneficial effect when treating of bone cancer pain.