Short-term Effect of Intravitreal Injection of Ranibizumab (Lucentis) on Intraocular Pressure
Short-term Effect of Intravitreal Injection of Ranibizumab (Lucentis) on Intraocular Pressure
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DOI：
10.1097/ijg.0b013e31819c4893
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发表时间：
2009-12-01
影响因子：
2
通讯作者：
Brusini, Paolo
中科院分区：
文献类型：
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作者：
Gismondi, Maurizio;Salati, Carlo;Brusini, Paolo
目的：探讨玻璃体腔内注射雷比珠单抗对眼压的短期影响。材料与方法：前瞻性研究湿性老年性黄斑变性患者54例(1眼)，年龄+-12岁。分别于术前、术后即刻、术后5秒、5、10、15、30、60分钟、1天进行眼压测定。对24只眼进行眼轴长度测量(超声生物测量法)。分析不同时间点、有晶状体眼与人工晶状体眼的眼压差异以及眼轴与眼压升高的关系。结果：平均眼压为16.3+/-3.0 mm Hg(12.0~21.3)。44.1+/-10.6(22.0至59.3)、29.0+/-9.6(15.0至49.0)。25.8+/-7.9(16.0至45.0)、23.7+/-6.6(15.7至39.0)、21.9+/-5.6(14.7至37.0)。即刻、IVIL后5秒、5、10、15、30、60分钟和第一天的时间点分别为18.8+/-6.1(10.0~35.0)和16.1+/-3.0(11.0~21.0)。IVIL前、后5秒、5.10、15、30min眼压差异有统计学意义(P=0.0001)，1h后差异无统计学意义(P=0.064)，第1天差异无统计学意义(P=0.449)。有晶状体眼与人工晶状体眼之间差异无统计学意义(P>；0.05)。眼轴较短与5秒后眼压升高有显著相关性(直线回归分析，R2=0.28，P=0.007)。结论：ILIL可引起眼压的短期升高。IVIL后，有晶状体眼和人工晶状体眼的眼压在注射后0到30分钟均有统计学意义的升高，且在较短的眼中表现得更明显。
Purpose: To investigate short-term effect on intraocular pressure (IOP) after intravitreal injection of ranibizumab (Lucentis) (IVIL).Materials and Methods: This prospective study included 1 eye of 54 patients (64 +/- 12 y) with wet age-related macular degeneration treated with IVIL. IOP measurements with TonoPen were taken: immediately before and 5 seconds, 5, 10, 15, 30 60 minutes, and 1 day after IVIL. Axial length (with ultrasound biometry) was assessed in 24 eyes. The analysis included IOP difference at various time points and between phakic and pseudophakic eyes and the relationship between axial length and IOP increases after 5 seconds.Results: Mean IOP were 16.3 +/- 3.0 mm Hg (range: 12.0 to 21.3). 44.1 +/- 10.6 (22.0 to 59.3), 29.0 +/- 9.6 (15.0 to 49.0). 25.8 +/- 7.9 (16.0 to 45.0), 23.7 +/- 6.6 (15.7 to 39.0), 21.9 +/- 5.6 (14.7 to 37.0). 18.8 +/- 6.1 (10.0 to 35.0), and 16.1 +/- 3.0 (11.0 to 21.0), respectively, for time points immediately before, 5 seconds, 5, 10, 15, 30, 60 minutes, and I day after IVIL. Differences between before IVIL and after IVIL IOP were statistically significant after 5 seconds, 5. 10, 15, and 30 minutes (P = 0.0001); however, were not significant after 1 hour (P = 0.064) and I day (P = 0.449). Differences between phakic and pseudophakic eyes were not significant (P > 0.05). The relationship between shorter axial length and IOP increase after 5 seconds was significant (linear regression analysis; R-2 = 0.28, P = 0.007).Conclusions: IVIL causes a considerable short-term transient rise in IOP. The IOP increase after IVIL can be statistically significant at 0 to 30 minutes after injection in both phakic and pseudophakic eyes, and tends to be greater in shorter eyes.