A case of abnormal growth hormone secretion possibly caused by low somatomedin production of unknown origin: is the unresponsiveness of GH receptor responsible for it?
A case of abnormal growth hormone secretion possibly caused by low somatomedin production of unknown origin: is the unresponsiveness of GH receptor responsible for it?
复制标题
生长激素分泌异常可能是由于来源不明的生长调节素产生量低引起的：生长激素受体无反应是否是其原因？
DOI：
10.1507/endocrj.43.suppl_s85
复制
发表时间：
1996
影响因子：
2
通讯作者：
K. Sakai
中科院分区：
文献类型：
--
作者：
M. Shiratsuchi;T. Okajima;K. Inoue;T. Takahashi;M. Yamamoto;K. Sakai
胰岛素样生长因子I（IGF-I）是最重要的生长调节因子，在GH刺激后在肝脏和其他组织中产生。因此，血清IGF-I水平取决于GH分泌。GH分泌过多导致高IGF-I水平，GH缺乏导致低IGF-I水平。然而，在蛋白质-热量营养不良[1]、肝脏疾病、不受控制的糖尿病[2]和Laron侏儒症[3]等病理条件下，尽管GH分泌正常或增加，但IGF-I水平仍较低。在本文中，我们提出了一个案例，低IGF-I的生产与GH分泌过多，发生在类风湿关节炎（RA）和糖尿病（DM）患者。虽然IGF-I产生低的原因尚不清楚，但我们研究了GH受体无反应性是否存在于
INSULIN-like growth factor I (IGF-I), the most important somatomedin, is produced in the liver and other tissues following stimulation by GH. Serum IGF-I levels are therefore dependent on GH secretion. GH hypersecretion induces high IGF-I levels and GH deficiency causes low IGF-I levels. However, low IGF-I levels in spite of normal or increased GH secretion are observed in such pathological conditions as protein-calorie malnutrition [1], liver diseases, uncontrolled diabetes mellitus [2] and Laron dwarfism [3]. In this paper, we present a case of low IGF-I production with GH hypersecretion which occurred in a patient with rheumatoid arthritis (RA) and diabetes mellitus (DM). Although the causes of low IGF-I production were unknown, we investigated whether GH receptor unresponsiveness was present in the