Computed tomography perfusion of squamous cell carcinoma of the upper aerodigestive tract -: Initial results
Computed tomography perfusion of squamous cell carcinoma of the upper aerodigestive tract -: Initial results
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DOI：
10.1097/00004728-200309000-00005
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发表时间：
2003-09-01
影响因子：
1.3
通讯作者：
Mukherji, SK
中科院分区：
文献类型：
--
作者：
Gandhi, D;Hoeffner, EG;Mukherji, SK
目的：目的：探讨头颈部鳞状细胞癌的CT灌注成像特点。方法：对14例未经治疗的头颈部鳞状细胞癌患者进行头颈部CT灌注成像。对于灌注研究，使用市售CT Perfusion 2软件（General Electric Medical Systems.密尔沃基，WI）在GE Advantage Windows工作站上。这产生了组织血容量分数（毫升/100克）、血流量（毫升）的参数图。100 g（-1）。min（-1））、平均通过时间（s）和微血管通透性表面积乘积（mL . 100 g（-1）。min（-1））。一位头颈部放射科医生分析了灌注数据。将感兴趣区域（ROI）放置在原发肿瘤部位、舌根和相邻肌肉群上。计算肿瘤组织血容量（BV）、血流量（BF）、平均通过时间（MTT）和毛细血管通透性表面积乘积（CP）的平均值，并与舌根和邻近肌肉组织的平均值进行比较。为了确定肿瘤和肌肉参数之间的统计学显着差异，Wilcoxon符号检验，配对data.Results的非参数检验，采用：CP，BF，BV的平均值高于原发性肿瘤（41.9，132.9，6.2，分别）比舌根或邻近的肌肉结构。与邻近的正常结构相比，原发性肿瘤中的MTT降低（4.0）。结论：我们获得了头颈部鳞状细胞癌的基线灌注数据，并将其与邻近正常结构进行了比较。我们的初步结果表明，CT灌注参数（CP、BF、BV和MTT）可用于帮助区分头颈部鳞状细胞癌（SCCA）与邻近正常组织。
Objective: To define the computed tomography (CT) perfusion characteristics of head and neck squamous cell carcinoma.Methods: Fourteen consecutive patients with untreated squamous cell cancers of head and neck underwent CT of the head and neck along with CT perfusion imaging through the primary site. For the perfusion studies, CT density changes in blood and tissues were kinetically analyzed using the commercially available CT Perfusion 2 software (General Electric Medical Systems. Milwaukee, WI) on a GE Advantage Windows workstation. This yielded parameter maps of fractional tissue blood volume (mL/100 g), blood flow (mL . 100 g(-1) . min(-1)), mean transit time (s), and microvascular permeability surface area product (mL . 100 g(-1) . min(-1)). One head and neck radiologist analyzed perfusion data. Regions of interest (ROI) were placed over the primary tumor site, tongue base, and adjacent muscle groups. The average values of tissue blood volume (BV), blood flow (BF), mean transit time (MTT), and capillary permeability surface area product (CP) were then calculated for the tumor and compared with the average values for the tongue base and adjacent musculature. To determine a statistically significant difference between the tumor and muscle parameters, the Wilcoxon sign test, a nonparametric test for paired data, was employed.Results: The average values of CP, BF, and BV were higher in primary tumor (41.9, 132.9, 6.2, respectively) than in tongue base or adjacent muscular structures. The MTT was reduced in primary tumors (4.0) compared with adjacent normal structures. The above differences were statistically significant (P < 0.05).Conclusions: We obtained baseline perfusion data for head and neck squamous cell cancers and compared it with adjacent normal structures. Our initial results suggest that CT perfusion parameters (CP, BF, BV, and MTT) can be used to help differentiate head and neck squamous cell carcinoma (SCCA) from adjacent normal tissue.