A single IL28B genotype SNP rs12979860 determination predicts treatment response in patients with chronic hepatitis C Genotype 1 virus
A single IL28B genotype SNP rs12979860 determination predicts treatment response in patients with chronic hepatitis C Genotype 1 virus
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DOI：
10.1097/meg.0b013e328349d0ef
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发表时间：
2011-10-01
影响因子：
2.1
通讯作者：
Dessein, Alain
中科院分区：
文献类型：
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作者：
Halfon, Philippe;Bourliere, Marc;Dessein, Alain
背景 最近的研究表明，宿主遗传学可能有助于预测药物反应，并支持在治疗丙型肝炎病毒 (HCV)-1 感染患者时应研究 IL28B 的单多核苷酸多态性 (SNP) 的建议。本研究的目的是确定单个 IL-28B 基因型 SNP rs8099917 或 rs12979860 测定是否足以预测慢性 HCV 患者的治疗失败。方法 总共纳入 198 名患者；平均（+/- 标准差）年龄为 47 +/- 12 岁，其中 140 名 (71%) 为男性。 156 名 (79%) 患者感染 HCV 基因型 1，42 名 (21%) 患者感染 HCV 基因型 2 或 3。108 名 (55%) 患者出现持续病毒学应答 (SVR)。分析了IL-28B中的两个SNP（rs8099917和rs12979860）。结果共有115名（58％）患者具有rs8099917 TT基因型，61名（31％）患者具有rs12979860 CC基因型。 Rs8099917 TT 和 rs12979860 CC 基因型与 HCV 基因型 1 患者的 SVR 相关[分别为比值比 = 2.60 (1.36-5.00)、P = 0.004 和比值比 = 3.30 (1.58-6.90)、P = 0.03]。在 HCV 基因型 2 或 3 患者中，未发现 SNP 与 SVR 之间存在关联。 结论 这项研究证实，单独使用 SNP rs8099917 和 rs12979860 可能有助于预测 HCV 治疗的结果。在一种合理且具有成本效益的方法中，仅确定这两个 SNP 之一就足以预测 SVR。由于与 rs8099917 TT 相比，与 rs12979860 CC 相关的预测性 SVR 最高（各自的阳性预测值：72% 与 63%，P = ns），因此仅测定 rs12979860 就足以预测干扰素反应。 Eur J Gastroenterol Hepatol 23:931-935 (C) 2011 Wolters Kluwer Health |利平科特·威廉姆斯和威尔金斯。
Background Recent studies have suggested that host genetics may be useful for predicting drug response and have supported the recommendation that single polynucleotide polymorphisms (SNPs) of IL28B should be investigated when treating hepatitis C virus (HCV)-1 infected patients. The aim of this study was to determine whether a single IL-28B genotype SNP rs8099917 or rs12979860 determination is sufficient to predict treatment failure in patients with chronic HCV.Methods A total of 198 patients were included; mean (+/- standard deviation) age was 47 +/- 12 years and 140 (71%) were men. One hundred and fifty-six (79%) patients were infected with HCV genotype 1 and 42 (21%) with HCV genotypes 2 or 3. One hundred and eight (55%) patients had sustained virologic response (SVR). Two SNPs in the IL-28B were analyzed (rs8099917 and rs12979860).Results A total of 115 (58%) patients had rs8099917 TT genotype and 61 (31%) had rs12979860 CC genotype. Rs8099917 TT and rs12979860 CC genotypes were associated with SVR in HCV genotype 1 patients [odds ratio = 2.60 (1.36-5.00), P = 0.004 and odds ratio = 3.30 (1.58-6.90), P = 0.03 respectively]. No association was found between SNPs and SVR in HCV genotype 2 or 3 patients.Conclusion This study confirms that SNPs rs8099917 and rs12979860 used alone may be useful for predicting the outcome of HCV treatment. In a rational and cost-effective approach, determination of only one of these two SNPs is sufficient for predicting SVR. Because of the highest predictive SVR associated with rs12979860 CC compared with the rs8099917 TT (respective positive predictive value: 72% vs. 63%, P = ns), rs12979860 determination alone is sufficient for predicting interferon response. Eur J Gastroenterol Hepatol 23:931-935 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.