Resting-state functional connectivity of brain regions involved in cognitive control, motivation, and reward is enhanced in obese females
Resting-state functional connectivity of brain regions involved in cognitive control, motivation, and reward is enhanced in obese females
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DOI：
10.3945/ajcn.113.080671
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发表时间：
2014-08-01
影响因子：
7.1
通讯作者：
Veer, Ilya M.
中科院分区：
文献类型：
--
作者：
Lips, Mirjam A.;Wijngaarden, Marjolein A.;Veer, Ilya M.
背景资料：目的：我们假设：1）肥胖和瘦型个体的能量平衡和奖赏相关的脑回路在功能连接模式上存在差异; 2）肥胖和瘦型个体的食物摄入对功能连接的影响存在差异。因此，我们比较了下丘脑、杏仁核和后扣带皮层的连通性，每一个都探测了肥胖受试者和瘦受试者在空腹状态和进食后与能量稳态和奖励相关的不同网络。设计：我们在46名肥胖女性参与者中获得了3个特斯拉静息态功能磁共振成像扫描，这些扫描是在过夜禁食和摄入液体混合餐后进行的。19例葡萄糖耐量正常，27例2型糖尿病（T2 DM）]和12例瘦型受试者。我们感兴趣的区域的功能连接进行了评估，通过使用种子为基础的相关approach.Results：正常葡萄糖耐量和T2 DM受试者之间没有显着差异。在禁食状态下，完全肥胖组的下丘脑与内侧前额叶皮质和背侧纹状体的连接性比瘦的受试者更强。肥胖者的杏仁核与右侧杏仁核的联系与瘦人不同。食物摄入量抑制下丘脑连接与额叶区域瘦科目，而这些连接几乎没有影响肥胖subjects.Conclusions：我们的研究结果表明，在几个大脑网络的功能连接，特别是稳态和认知控制网络和奖励网络，是不同的肥胖和瘦科目。在禁食状态下，肥胖似乎与参与认知控制，动机和奖励的大脑区域之间的功能连接有关，而与瘦受试者相比，肥胖者的这些连接在很大程度上不受食物摄入的影响。
Background: The brain is crucial for the control of food intake, reward, and energy homeostasis.Objective: We hypothesized that 1) brain circuits involved in energy homeostasis and reward show different functional connectivity patterns between obese and lean individuals and 2) food intake affects functional connectivity differentially in obese and lean individuals. Therefore, we compared the connectivity of the hypothalamus, amygdala, and posterior cingulate cortex, each probing a distinct network related to energy homeostasis and reward, between obese subjects and lean subjects in the fasting state and after meal ingestion.Design: We acquired 3 Tesla resting-state functional magnetic resonance imaging scans after an overnight fast and after ingestion of a liquid mixed meal in 46 obese female participants [19 with normal glucose tolerance and 27 with type 2 diabetes mellitus (T2DM)] and 12 lean subjects. Functional connectivity of our regions of interest was assessed by using a seed-based correlation approach.Results: No significant differences between normal-glucose-tolerant and T2DM subjects were observed. In the fasting state, the total obese group had stronger hypothalamic connectivity with the medial prefrontal cortex and the dorsal striatum than did the lean subjects. The amygdala was differentially connected to the right insula in obese compared with lean subjects. Food intake dampened hypothalamic connectivity with the frontal regions in lean subjects, whereas these connections were barely affected in obese subjects.Conclusions: Our results indicate that functional connectivity in several brain networks, particularly the homeostatic and cognitive control network and the reward network, was different between obese and lean subjects. In the fasting state, obesity appears to be associated with stronger functional connectivity between brain areas involved in cognitive control, motivation, and reward, whereas these connections are largely unaffected by food intake in obese compared with lean subjects.