Targets for Combating the Evolution of Acquired Antibiotic Resistance.
Targets for Combating the Evolution of Acquired Antibiotic Resistance.
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DOI：
10.1021/acs.biochem.5b00109
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发表时间：
2015-06-16
期刊：
影响因子：
2.9
通讯作者：
Kohli, Rahul M.
中科院分区：
文献类型：
--
作者：
Culyba, Matthew J.;Mo, Charlie Y.;Kohli, Rahul M.
细菌对抗生素的反应具有快速适应和进化的非凡能力。获得性抗生素耐药可通过多种机制产生，但通常涉及改变药物的靶点，酶使药物失活或阻止药物接近其靶点。这些机制涉及病原体中导致遗传抗性的新遗传变化。这种认识强调了理解这种基因变化如何产生的重要性。在这里，我们回顾了我们对抗生素耐药性进化过程的理解的最新进展，特别关注由SOS途径和水平基因转移介导的超突变。我们探讨了获得性耐药的分子机制，并讨论了它们作为潜在靶点的可行性。我们建议对这些适应机制的进一步研究不仅可以提供对进化的见解，还可以提供增强我们当前抗生素库的策略。
Bacteria possess a remarkable ability to rapidly adapt and evolve in response to antibiotics. Acquired antibiotic resistance can arise by multiple mechanisms but commonly involves altering the target site of the drug, enzymatically inactivating the drug, or preventing the drug from accessing its target. These mechanisms involve new genetic changes in the pathogen leading to heritable resistance. This recognition underscores the importance of understanding how such genetic changes can arise. Here, we review recent advances in our understanding of the processes that contribute to the evolution of antibiotic resistance, with a particular focus on hypermutation mediated by the SOS pathway and horizontal gene transfer. We explore the molecular mechanisms involved in acquired resistance and discuss their viability as potential targets. We propose that additional studies into these adaptive mechanisms not only can provide insights into evolution but also can offer a strategy for potentiating our current antibiotic arsenal.
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影响因子：
64.8
作者：
Beaber, JW;Hochhut, B;Waldor, MK
通讯作者：
Waldor, MK
DOI：
10.1126/science.1176667
发表时间：
2009-08-28
期刊：
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作者：
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通讯作者：
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DOI：
10.1126/science.1220761
发表时间：
2012-08-31
期刊：
Science (New York, N.Y.)
影响因子：
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通讯作者：
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