HCN: A plausible source of purines, pyrimidines and amino acids on the primitive earth
HCN: A plausible source of purines, pyrimidines and amino acids on the primitive earth
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HCN：原始地球上嘌呤、嘧啶和氨基酸的合理来源
DOI：
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发表时间：
1978
影响因子：
3.9
通讯作者：
J. Lawless
中科院分区：
文献类型：
--
作者：
J. Ferris;Prakash C. Joshi;E. Edelson;J. Lawless
总结HCN的稀释（0.1M）溶液在pH 9.2下冷凝成低聚物。这些低聚物的水解产生4，5-二羟基嘧啶、乳清酸、5-羟基尿嘧啶、腺嘌呤、4-氨基咪唑-5-甲酰胺和氨基酸。这些结果，与早期的数据一起，表明三个主要类别的含氮生物分子，嘌呤，嘧啶和氨基酸可能起源于原始地球上的HCN。乳清酸和4-氨基咪唑-5-甲酰胺的观察表明，核苷酸的当代生物合成途径可能是从HCN低聚物水解释放的化合物演变而来的。
SummaryDilute (0.1M) solutions of HCN condense to oligomers at pH 9.2. Hydrolysis of these oligomers yields 4,5-dihydroxypyrimidine, orotic acid, 5-hydroxyuracil, adenine, 4-aminoimidazole-5-carboxamide and amino acids. These results, together with the earlier data, demonstrate that the three main classes of nitrogen-containing biomolecules, purines, pyrimidines and amino acids may have originated from HCN on the primitive earth. The observation of orotic acid and 4-aminoimidazole-5-carboxamide suggests that the contemporary biosynthetic pathways for nucleotides may have evolved from the compounds released on hydrolysis of HCN oligomers.