ADENOSINE INHIBITION OF MESOPONTINE CHOLINERGIC NEURONS - IMPLICATIONS FOR EEG AROUSAL
ADENOSINE INHIBITION OF MESOPONTINE CHOLINERGIC NEURONS - IMPLICATIONS FOR EEG AROUSAL
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DOI：
10.1126/science.8303279
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发表时间：
1994-02-04
期刊：
影响因子：
56.9
通讯作者：
GREENE, RW
中科院分区：
文献类型：
--
作者：
RAINNIE, DG;GRUNZE, HCR;GREENE, RW
脑桥中胆碱能神经元的放电活动增加参与了脑电(EEG)觉醒的产生；这种觉醒随着先前觉醒或脑高温的持续时间而减弱。脑干切片上的全细胞和细胞外记录显示，中桥脑胆碱能神经元受到内源性腺苷的紧张性抑制控制，腺苷是大脑代谢过程中释放的一种神经调节剂。这种抑制音是通过向内整流钾电导和抑制超极化激活电流在突触后介导的。这些数据提供了一种耦合机制，将脑电唤醒的神经元控制与事先觉醒、大脑温度过高以及使用腺苷受体阻滞剂咖啡因和茶碱的影响联系起来。
Increased discharge activity of mesopontine cholinergic neurons participates in the production of electroencephalographic (EEG) arousal; such arousal diminishes as a function of the duration of prior wakefulness or of brain hyperthermia. Whole-cell and extracellular recordings in a brainstem slice show that mesopontine cholinergic neurons are under the tonic inhibitory control of endogenous adenosine, a neuromodulator released during brain metabolism. This inhibitory tone is mediated postsynaptically by an inwardly rectifying potassium conductance and by an inhibition of the hyperpolarization-activated current. These data provide a coupling mechanism linking neuronal control of EEG arousal with the effects of prior wakefulness, brain hyperthermia, and the use of the adenosine receptor blockers caffeine and theophylline.