Virus-derived anti-inflammatory proteins: potential therapeutics for cancer.
Virus-derived anti-inflammatory proteins: potential therapeutics for cancer.
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DOI：
10.1016/j.molmed.2012.03.006
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发表时间：
2012-06
影响因子：
13.6
通讯作者：
Donghang Zheng;Hao Chen;M. Bartee;Jennifer M Williams;J. Davids;E. Huang;J. Moreb;A. Lucas
中科院分区：
文献类型：
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作者：
Donghang Zheng;Hao Chen;M. Bartee;Jennifer M Williams;J. Davids;E. Huang;J. Moreb;A. Lucas
现在，炎症反应在癌细胞的生长、侵袭和转移中起着明确的核心作用。来自病毒的抗炎蛋白针对免疫反应途径中的关键阶段，并具有作为癌症新疗法的潜力，包括已确定的高度有效的病毒衍生的蛋白酶、趋化因子、细胞因子和凋亡级联抑制物。丝氨酸蛋白酶，除了在血栓形成、溶栓和凋亡途径中的常规作用外，还是炎症的重要调节因子，并与癌症的发生有关。趋化因子驱动其他炎症反应途径，在细胞侵袭和激活以及建立肿瘤微环境、调节免疫细胞渗透、癌细胞增殖、转移和血管生成等方面发挥核心作用。本文就病毒免疫调节蛋白作为抗癌药物的作用机制和应用前景作一综述。
Inflammatory responses now have a defined central role in cancer cell growth, invasion, and metastases. Anti-inflammatory proteins from viruses target key stages in immune response pathways and have potential as novel therapeutics for cancer, including highly potent virus-derived inhibitors of protease, chemokine, cytokine, and apoptotic cascades that have been identified. Serine proteases, in addition to their conventional roles in thrombosis, thrombolysis, and apoptotic pathways, are essential regulators of inflammation and are associated with developing cancers. Chemokines drive other inflammatory response pathways with central roles in cell invasion and activation as well as establishing the microenvironment of tumors, modulating immune cell infiltration, cancer cell proliferation, metastasis, and angiogenesis. This review focuses on the mechanisms of action and potential for application of viral immunomodulatory proteins as anticancer therapeutics.