Reduced aqueous humour ascorbic-acid concentration in women with smaller anterior chamber depth
Reduced aqueous humour ascorbic-acid concentration in women with smaller anterior chamber depth
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DOI：
10.1038/s41598-018-36899-8
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发表时间：
2019-01-23
影响因子：
4.6
通讯作者：
Senoo, Tadashi
中科院分区：
文献类型：
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作者：
Ito, Sakae;Sairenchi, Toshimi;Senoo, Tadashi
短前房深度（ACD）被认为是超声乳化术后内皮细胞丢失的危险因素。然而，它是否是一个独立的危险因素仍然存在争议。我们研究了抗坏血酸（AA）浓度之间的关系，在房水（AqH）和ACD。我们分析了97例接受小切口白内障手术的患者（42例男性和55例女性）的165份AqH样本。采用高效液相色谱-电化学检测法测定AqH和血浆AA浓度。患者的特征进行了比较之间和性别内。结果表明，年龄和ACD与AqH AA浓度仅在女性中有显著相关性（r =-0.206，P = 0.045; r = 0.339，P < 0.001）。血浆AA浓度与AqH AA浓度呈显著正相关（r = 0.420，P < 0.001; r = 0.316，P = 0.002）。在调整混杂因素（年龄和血浆AA浓度）后，ACD与AqH AA浓度仅在女性中呈显著正相关（部分r = 0.275，P = 0.009）。总之，AqH AA浓度在ACD较小的女性中降低。这可能表明，患有短ACD的女性可能更容易受到氧化损伤。
Short anterior chamber depth (ACD) is considered a risk factor of endothelial-cell loss after phacoemulsification. However, whether it is an independent risk factor or not remains controversial. We investigated the relationship between ascorbic acid (AA) concentrations in the aqueous humour (AqH) and ACD. We analysed 165 AqH samples of 97 patients (42 men and 55 women) who underwent small incision cataract surgery. AqH and plasma AA concentrations were measured using a high-performance liquid chromatography - electrochemical detection method. Patient characteristics were compared between and within the sexes. As a result, age and ACD were significantly correlated with AqH AA concentrations (r = -0.206, P = 0.045; r = 0.339, P < 0.001) only in women. Moreover, plasma AA concentrations were significantly correlated with AqH AA concentrations (r = 0.420, P < 0.001; r = 0.316, P = 0.002) both in men and women. After adjusting for confounding factors (age and plasma AA concentrations), ACD was significantly and positively correlated with AqH AA concentrations (partial.r = 0.275, P = 0.009) only in women. In conclusion, AqH AA concentrations were reduced in women with smaller ACD. This may suggest that women with short ACD could be more susceptible to oxidative damage.