The Effect of Age on T-Regulatory Cell Number and Function in Patients With Asthma.
The Effect of Age on T-Regulatory Cell Number and Function in Patients With Asthma.
复制标题
DOI：
10.4168/aair.2021.13.4.646
复制
发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Busse PJ
中科院分区：
文献类型：
--
作者：
Birmingham JM;Chesnova B;Wisnivesky JP;Calatroni A;Federman J;Bunyavanich S;Busse PJ
调节性T细胞（T-regulatory cells，TCFs）在抑制效应细胞和维持自身耐受中起着关键作用。对年轻成人和儿童的研究表明，TcB的分化不足和功能缺陷可能有助于哮喘的发展;然而，老年哮喘患者的数据有限。为了解决年龄对Treg频率和功能与临床结果的关系的影响，我们收集了老年（> 60岁）和年轻（20-40岁）哮喘患者的诱导痰（分类细胞计数和Treg频率）和外周血（Treg功能和频率）。在年轻患者中，低Treg抑制与急诊科（艾德）的平均数量显著较高相关。（1.8 vs. 0.17，P = 0.02）和紧急护理访视（2.3 vs. 0.17，P = 0.01），哮喘控制下降（平均哮喘控制测试[ACT]评分，17 vs. 21.3，P = 0.01）。然而，在老年患者中，较低的Treg功能与ACT评分（18.2 vs. 13.4，P = 0.10）或艾德（P = 0.9）或紧急护理访视（P = 0.2）的数量无关。我们的数据表明，在老年患者中，TdR与哮喘控制和临床哮喘结局的关系较弱，与年轻患者中的发现不同，TdR更有可能发挥保护作用。
T-regulatory cells (Tregs) play a key role in suppressing effector cells and maintaining self-tolerance. Studies of younger adults and children suggest that insufficient differentiation and functional defects of Tregs may contribute to the development of asthma; however, data from older patients with asthma are limited. To address the effects of aging on the relationship of Treg frequency and function with clinical outcomes, we collected induced sputum (differential cell count and Treg frequency) and peripheral blood (Treg function and frequency) from aged (> 60 years of age) and younger (20–40 years old) patients with asthma. In younger patients, low Treg suppression was associated with significantly higher mean numbers of emergency department (ED) (1.8 vs. 0.17, P = 0.02) and urgent care visits (2.3 vs. 0.17, P = 0.01) for asthma, and decreased asthma control (mean Asthma Control Test [ACT] score, 17 vs. 21.3, P = 0.01) compared to those with high Treg suppression. In older patients, however, a lower Treg function was not significantly associated with ACT scores (18.2 vs. 13.4, P = 0.10), or the number of ED (P = 0.9) or urgent care visits (P = 0.2). Our data suggest that Tregs have a weak relationship with asthma control and clinical asthma outcomes in older patients and differ from findings in younger patients, where Tregs are more likely to play a protective role.