Cellular senescence in age-related disorders.
Cellular senescence in age-related disorders.
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DOI：
10.1016/j.trsl.2020.06.007
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Farr JN
中科院分区：
文献类型：
--
作者：
Kaur J;Farr JN
大部分人口现在面临着与年龄有关的慢性病的巨大负担。老年科学的最新发现表明，可以通过靶向细胞衰老来操纵模型生物（如小鼠）的健康寿命，细胞衰老是衰老的标志性机制，被定义为当细胞经历致癌或其他不同形式的损伤时发生的不可逆增殖停滞。衰老细胞和它们的促炎分泌组已经成为与年龄相关的组织功能障碍和发病率的贡献者。细胞衰老在介导骨质疏松症、虚弱、心血管疾病、骨关节炎、肺纤维化、肾脏疾病、神经退行性疾病、肝脂肪变性和代谢功能障碍中具有因果作用。在小鼠中治疗靶向衰老细胞可以预防，延迟或减轻这些疾病中的每一种。因此，选择性消除衰老细胞或干扰其促进组织功能障碍的能力的衰老方法，包括senolytics和senomorphics，正在获得势头，作为消除人类衰老的潜在现实策略，从而压缩发病率并延长健康寿命。
Much of the population is now faced with an enormous burden of age-associated chronic diseases. Recent discoveries in geroscience indicate that healthspan in model organisms such as mice can be manipulated by targeting cellular senescence, a hallmark mechanism of aging, defined as an irreversible proliferative arrest that occurs when cells experience oncogenic or other diverse forms of damage. Senescent cells and their pro-inflammatory secretome have emerged as contributors to age-related tissue dysfunction and morbidity. Cellular senescence has causal roles in mediating osteoporosis, frailty, cardiovascular diseases, osteoarthritis, pulmonary fibrosis, renal diseases, neurodegenerative diseases, hepatic steatosis, and metabolic dysfunction. Therapeutically targeting senescent cells in mice can prevent, delay, or alleviate each of these conditions. Therefore, senotherapeutic approaches, including senolytics and senomorphics, that either selectively eliminate senescent cells or interfere with their ability to promote tissue dysfunction, are gaining momentum as potential realistic strategies to abrogate human senescence to thereby compress morbidity and extend healthspan.
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影响因子：
82.9
作者：
Farr JN;Xu M;Weivoda MM;Monroe DG;Fraser DG;Onken JL;Negley BA;Sfeir JG;Ogrodnik MB;Hachfeld CM;LeBrasseur NK;Drake MT;Pignolo RJ;Pirtskhalava T;Tchkonia T;Oursler MJ;Kirkland JL;Khosla S
通讯作者：
Khosla S
影响因子：
64.8
作者：
Baker DJ;Childs BG;Durik M;Wijers ME;Sieben CJ;Zhong J;Saltness RA;Jeganathan KB;Verzosa GC;Pezeshki A;Khazaie K;Miller JD;van Deursen JM
通讯作者：
van Deursen JM
影响因子：
16.6
作者：
Fuhrmann-Stroissnigg H;Ling YY;Zhao J;McGowan SJ;Zhu Y;Brooks RW;Grassi D;Gregg SQ;Stripay JL;Dorronsoro A;Corbo L;Tang P;Bukata C;Ring N;Giacca M;Li X;Tchkonia T;Kirkland JL;Niedernhofer LJ;Robbins PD
通讯作者：
Robbins PD
影响因子：
3.3
作者：
Freund A;Laberge RM;Demaria M;Campisi J
通讯作者：
Campisi J
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J