Performance on spatial working memory tasks after dorsal or ventral hippocampal lesions and adjacent damage to the subiculum.
Performance on spatial working memory tasks after dorsal or ventral hippocampal lesions and adjacent damage to the subiculum.
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DOI：
10.1037/0735-7044.120.2.413
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发表时间：
2006-04
影响因子：
1.9
通讯作者：
Olivier Potvin;K. Allen;Geneviève Thibaudeau;F. Doré;S. Goulet
中科院分区：
文献类型：
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作者：
Olivier Potvin;K. Allen;Geneviève Thibaudeau;F. Doré;S. Goulet
对背侧或腹侧海马兴奋性毒性损伤的大鼠和对照大鼠进行2项空间工作记忆任务的训练：8个诱饵臂的标准版本的径向迷宫和T迷宫中的非匹配位置程序。背侧病变产生的赤字，在这两个任务，而腹侧病变并没有影响他们的学习。下托损伤的体积分析表明，背海马病变造成的赤字，在不匹配的地方，只有当伴随着背下托的损害;另一方面，无论下托损伤的程度，背海马损害的表现在径向臂迷宫。
Rats with excitotoxic lesions of the dorsal or ventral hippocampus and control rats were trained on 2 spatial working memory tasks: the standard version of the radial maze with 8 baited arms and the non-matching-to-place procedure in the T maze. Dorsal lesions produced deficits in both tasks, whereas ventral lesions did not affect learning in either of them. A volumetric analysis of subicular damage showed that dorsal hippocampal lesions caused a deficit in the non-matching-to-place only when accompanied by damage to the dorsal subiculum; on the other hand, lesions to the dorsal hippocampus impaired performance in the radial-arm maze regardless of the extent of subicular damage.