The synaptic impact of the host immune response in a parkinsonian allograft rat model: Influence on graft-derived aberrant behaviors.
The synaptic impact of the host immune response in a parkinsonian allograft rat model: Influence on graft-derived aberrant behaviors.
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DOI：
10.1016/j.nbd.2008.06.018
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发表时间：
2008-11
影响因子：
6.1
通讯作者：
Steece-Collier K
中科院分区：
文献类型：
--
作者：
Soderstrom KE;Meredith G;Freeman TB;McGuire SO;Collier TJ;Sortwell CE;Wu Q;Steece-Collier K
Graft-induced dyskinesias (GIDs), side-effects found in clinical grafting trials for Parkinson’s disease (PD), may be associated with the withdrawal of immunosuppression. The goal of this study was to determine the role of the immune response in GIDs. We examined levodopa-induced dyskinesias (LIDs), GIDs-like behaviors, and synaptic ultrastructure in levodopa-treated, grafted, parkinsonian rats with mild (sham), moderate (allografts) or high (allografts plus peripheral spleen cell injections) immune activation. Grafts attenuated amphetamine-induced rotations and LIDs, but two abnormal motor syndromes (tapping stereotypy, litter retrieval/chewing) emerged and increased with escalating immune activation. Immunohistochemical analyses confirmed immune activation and graft survival. Ultrastructural analyses showed increases in tyrosine hydroxylase-positive (TH+) axo-dendritic synapses, TH+ asymmetric specializations, and non-TH+ perforated synapses in grafted, compared to intact, striata. These features were exacerbated in rats with the highest immune activation and correlated statistically with GIDs-like behaviors, suggesting immune-mediated aberrant synaptology may contribute to graft-induced aberrant behaviors.
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影响因子：
6.1
作者：
Carlsson, T;Winkler, C;Kirik, D
通讯作者：
Kirik, D
影响因子：
3.3
作者：
FISHER, LJ;YOUNG, SJ;GAGE, FH
通讯作者：
GAGE, FH
影响因子：
3.3
作者：
Duan, WM;Brundin, P;Widner, H
通讯作者：
Widner, H
影响因子：
56.9
作者：
Beattie, EC;Stellwagen, D;Malenka, RC
通讯作者：
Malenka, RC
影响因子：
3.3
作者：
GROVES, PM;LINDER, JC;YOUNG, SJ
通讯作者：
YOUNG, SJ