LOSARTAN IN HEART-FAILURE - HEMODYNAMIC-EFFECTS AND TOLERABILITY
LOSARTAN IN HEART-FAILURE - HEMODYNAMIC-EFFECTS AND TOLERABILITY
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DOI：
10.1161/01.cir.91.3.691
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发表时间：
1995-02-01
期刊：
影响因子：
37.8
通讯作者：
RUCINSKA, E
中科院分区：
文献类型：
--
作者：
CROZIER, I;IKRAM, H;RUCINSKA, E
方法和结果采用多中心、安慰剂对照、口服、多剂量(2.5、10、25和50 mg，每天一次)氯沙坦治疗有症状性心力衰竭和左心功能受损(射血分数)的患者进行双盲对照研究
Background The aim of the present study was to assess the short- and long-term effects of multiple doses of the angiotensin II receptor antagonist losartan in heart failure.Methods and Results A multicenter, placebo-controlled, oral, multidose (2.5, 10, 25, and 50 mg losartan once daily) double-blind comparison in patients with symptomatic heart failure and impaired left ventricular function (ejection fraction