Intestinal permeability and orocaecal transit time in elderly patients with Parkinson's disease
Intestinal permeability and orocaecal transit time in elderly patients with Parkinson's disease
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DOI：
10.1136/pgmj.72.845.164
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发表时间：
1996-03-01
影响因子：
5.1
通讯作者：
Barrett, JA
中科院分区：
文献类型：
--
作者：
Davies, KN;King, D;Barrett, JA
帕金森病患者体重减轻的病因可能是多因素的。我们研究了15名帕金森病患者和15名年龄和性别匹配的对照组，并寻找小肠细菌过度生长或肠道通透性改变导致吸收不良的证据。尽管乳果糖氢呼气试验没有显示小肠细菌污染的证据，但帕金森病患者的口盲部通过时间显著增加。通过糖吸收差异试验测量的肠渗透性也紊乱。帕金森病患者甘露醇吸收减少，而乳果糖吸收在两组中相似，表明帕金森病患者肠上皮细胞刷状缘膜的非介导吸收减少。
The aetiology of weight loss in patients with Parkinson's disease is likely to be multifactorial. We studied 15 patients with Parkinson's disease and 15 age- and sex-matched controls and looked for evidence of malabsorption due to small bowel bacterial overgrowth or alteration of intestinal permeability. There was a marked increase in orocaecal transit time in the patients with Parkinson's disease, although lactulose hydrogen breath testing did not show evidence of small bowel bacterial contamination. intestinal permeability measured by the differential sugar absorption test was also deranged. There was reduced absorption of mannitol in patients with Parkinson's disease while lactulose absorption was similar in both groups, suggesting decreased non-mediated uptake across the enterocyte brush border membrane in patients with Parkinson's disease.