Lyme borreliosis
Lyme borreliosis
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DOI：
10.1016/s0140-6736(11)60103-7
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发表时间：
2012-02-04
期刊：
影响因子：
168.9
通讯作者：
Strle, Franc
中科院分区：
文献类型：
--
作者：
Stanek, Gerold;Wormser, Gary P.;Strle, Franc
莱姆病（莱姆病）是由伯氏疏螺旋体的螺旋体引起的，由蜱虫传播。最常见的临床表现是移动性红斑，即使没有抗生素治疗，最终也会消退。然而，感染病原体可以扩散到其他组织和器官，引起更严重的症状，可能涉及患者的皮肤、神经系统、关节或心脏。这种疾病的发病率在许多国家都在增加。感染的实验室证据，主要是血清学，对于诊断是必不可少的，除非是典型的红斑移动性。确诊病例通常用抗生素治疗2-4周，大多数患者顺利康复。没有令人信服的证据支持使用抗生素超过4周，或支持在接受充分治疗的患者中螺旋体的持续存在。预防主要是防止蜱虫叮咬。目前还没有适用于人类的疫苗。
Lyme borreliosis (Lyme disease) is caused by spirochaetes of the Borrelia burgdorferi sensu lato species complex, which are transmitted by ticks. The most common clinical manifestation is erythema migrans, which eventually resolves, even without antibiotic treatment. However, the infecting pathogen can spread to other tissues and organs, causing more severe manifestations that can involve a patient's skin, nervous system, joints, or heart. The incidence of this disease is increasing in many countries. Laboratory evidence of infection, mainly serology, is essential for diagnosis, except in the case of typical erythema migrans. Diagnosed cases are usually treated with antibiotics for 2-4 weeks and most patients make an uneventful recovery. No convincing evidence exists to support the use of antibiotics for longer than 4 weeks, or for the persistence of spirochaetes in adequately treated patients. Prevention is mainly accomplished by protecting against tick bites. There is no vaccine available for human beings.