Anesthesiologists at work: an increase in pro-inflammatory and Th2 cytokine production, and alterations in proliferative immune responses.
Anesthesiologists at work: an increase in pro-inflammatory and Th2 cytokine production, and alterations in proliferative immune responses.
复制标题
工作中的麻醉师：促炎细胞因子和 Th2 细胞因子的产生增加，以及增殖性免疫反应的改变。
DOI：
10.1111/j.1399-6576.2006.01151.x
复制
发表时间：
2006
影响因子：
2.1
通讯作者：
Ben-Eliyahu,S
中科院分区：
文献类型：
--
作者：
Beilin,B;Greenfeld,K;Abiri,N;Yardeni,IZ;Bessler,H;Ben-Eliyahu,S
背景：麻醉师是酒精和药物滥用、抑郁、自杀和精神科住院的高危人群。他们的工作环境对特定免疫指标的影响几乎没有研究，人们假设免疫扰动可能导致上述风险中的一些。本研究利用一次为期3个月的意外罢工，探讨其与特定免疫指标的关系。方法：我们评估了10名麻醉师在罢工前、罢工结束时以及在长时间显著减少工作量后的血液中诱导的细胞因子产生和淋巴细胞增殖反应。结果：结果：罢工结束时，对植物血凝素(PHA)和刀豆蛋白A(ConA)的增殖反应明显降低。在这个时间点，我们观察到IL-6(IL-6)、IL-10和IL-1ra水平的产生显著下降，而IL-2的产生显著增加。结论：麻醉医师的工作状态与特定的免疫改变有关，包括向Th2型细胞因子占优势的转变和促炎细胞因子应答的升高。Th1水平降低与感染易感性增加有关，高促炎细胞因子水平最近被认为是心血管疾病和抑郁症的病因因素。
Background:Anesthesiologists are a population at high risk of alcohol and drug abuse, depression, suicide, and psychiatric hospitalization. The impact of their working milieu on specific immune indices has scarcely been studied, and it is assumed that immune perturbations may contribute to some of the above risks. This study took advantage of an unplanned, 3‐month long strike of anesthesiologists, and explored its relations to specific immune measures.Methods:We assessed induced cytokine production and lymphocytes proliferative responses in blood samples taken from 10 anesthesiologists just before the strike and at its end, after a long period of markedly reduced workload.Results:The results indicated that the proliferative responses to phytohemagglutinin (PHA) and concanavalin A (Con A) were significantly lower at the end of the strike. At this time point, we observed a significant decrease in the production of interleukin‐6 (IL‐6), IL‐10 and IL1ra levels, and a significant increase in IL‐2 production. A strong trend towards a decline in tumor necrosis factor‐α (TNF‐α) levels was evident, while levels of IL‐1β were unchanged.Conclusion:These findings suggest that the working conditions of anesthesiologists are associated with specific immune alterations, including a shift towards a Th2 cytokines’ dominance, and an elevated pro‐inflammatory cytokine response. A reduced Th1 profile has been related to increased susceptibility to infections, and high pro‐inflammatory cytokine levels were recently proposed as etiological factors in cardiovascular diseases and in depression.