Effects of interferon on sensitive and resistant L1210 cell lines.
Effects of interferon on sensitive and resistant L1210 cell lines.
复制标题
干扰素对敏感和耐药 L1210 细胞系的影响。
DOI：
10.1089/jir.1981.1.287
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
B. Lebleu
中科院分区：
文献类型：
--
作者：
J. Marti;P. Vandenbussche;M. Silhol;P. Milhaud;M. Verhaegen;J. Content;B. Lebleu
对干扰素的抗病毒和抗细胞作用耐药的L1210细胞不能诱导2，5A合成酶和蛋白激酶活性。克隆了一株抗性的L1210菌株，揭示了细胞群体在抗病毒和抗细胞反应以及蛋白激酶和2，5A合成酶诱导能力方面的异质性。真正具有干扰素抗性的L1210细胞的反应缺陷似乎存在于干扰素作用的早期阶段。
L1210 cells resistant to the antiviral and anticellular effects of interferon are not inducible for the 2,5A synthetase and for the protein kinase activities. Cloning of one resistant L1210 strain has revealed heterogeneity of the cell population with respect to their antiviral and anticellular response as well as protein kinase and 2,5A synthetase inducibility. The defect in the response of truly interferon-resistant L1210 cells appears to reside at an early step of interferon action.