Epigenetic transcriptional memory.
Epigenetic transcriptional memory.
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DOI：
10.1007/s00294-016-0661-8
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发表时间：
2017-06
期刊：
影响因子：
2.5
通讯作者：
Brickner JH
中科院分区：
文献类型：
--
作者：
D'Urso A;Brickner JH
生物体改变基因表达以适应环境条件的变化，如温度，营养，炎症信号和压力。在某些情况下，生物体可以“记住”以前的环境条件，并在未来更快地适应这种条件。表观遗传转录记忆对先前刺激的反应可以在生物体对相同刺激的反应中产生可遗传的变化，定量或定性地改变基因表达的变化。染色质变化在控制记忆过程中平衡RNAPII结合中的作用从酵母到人类都是保守的。在这里，我们讨论表观遗传转录记忆在不同的系统和我们目前的理解，其分子基础。我们最近的工作与一个良好的表征模型的转录记忆表明，记忆是由转录因子的结合，导致染色质结构的根本变化，并允许绑定的一个平衡的形式的RNA聚合酶II，促进未来的再激活率启动。
Organisms alter gene expression to adapt to changes in environmental conditions such as temperature, nutrients, inflammatory signals and stress. In some cases, organisms can “remember” a previous environmental condition and adapt to that condition more rapidly in the future. Epigenetic transcriptional memory in response to a previous stimulus can produce heritable changes in the response of an organism to the same stimulus, quantitatively or qualitatively altering changes in gene expression. The role of chromatin changes in controlling binding of poised RNAPII during memory are conserved from yeast to humans. Here we discuss epigenetic transcriptional memory in different systems and our current understanding of its molecular basis. Our recent work with a well-characterized model for transcriptional memory demonstrated that memory is initiated by binding of a transcription factor, leading to essential changes in chromatin structure and allowing binding of a poised form of RNA polymerase II, promoting the rate of future re-activation.