Discovery and development of anti-angiogenic peptides: A structural link.
Discovery and development of anti-angiogenic peptides: A structural link.
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DOI：
10.1023/b:agen.0000011730.94233.06
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发表时间：
2003-01-01
期刊：
影响因子：
9.8
通讯作者：
Mayo, Kevin H.
中科院分区：
文献类型：
--
作者：
Dings, Ruud P. M.;Nesmelova, Irina;Mayo, Kevin H.
癌症是一种由过度血管生成促进的疾病。干扰这一过程提出了一种有吸引力的方法来控制异常肿瘤生长，这一假说首次提出于20世纪70年代初，导致世界范围内的重点是识别和开发血管生成抑制剂，目前有数百种。本文综述了抗血管生成蛋白片段和多肽的发现和发展，并倾向于了解它们的结构-功能关系，以帮助设计更好的治疗药物。
Cancer is a disease promoted by excess angiogenesis. Interference with this process poses an attractive approach to controling aberrant tumor growth, a hypothesis first proposed in the early 1970s that led to world-wide focus on identifying and developing angiogenesis inhibitors, which currently number in the hundreds. This review surveys the discovery and development of anti-angiogenic protein fragments and peptides, with a slant towards understanding their structure-function relationships to aid in the design of better therapeutic agents.